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Effect of intravenous magnesium sulfate on chronic obstructive pulmonary disease exacerbations requiring hospitalization: A randomized placebo-controlled trial
Effect of intravenous magnesium sulfate on chronic obstructive pulmonary disease exacerbations requiring hospitalization: A randomized placebo-controlled trial
- Source :
- Respiratory Medicine: COPD Update. 2:114
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Objective Magnesium sulfate has been shown to have a bronchodilating effect in asthma, but this effect has not been clearly established in the context of chronic obstructive pulmonary disease (COPD). For this reason we investigated the possible bronchodilating effect of magnesium sulfate in COPD exacerbations. Patients and methods We studied 24 patients with exacerbated COPD who required admission to our hospital's pneumology department. All patients underwent baseline spirometry and were subsequently randomized to groups in a double-blind crossover design. Patients received 1.5 g of magnesium sulfate or placebo in an intravenous solution for 20 minutes. Those who received magnesium sulfate the first day were given placebo the second day, and vice versa. Spirometry was performed 15, 30, and 45 minutes after administration of magnesium sulfate or placebo. Finally, 400 μg of salbutamol were administered using a spacer and a final spirometry was performed 15 minutes later. All patients also received treatment with corticosteroids, intravenous antibiotics, oxygen, and regularly-scheduled bronchodilator therapy (salbutamol and ipratropium bromide every 6 hours). Results When we compared absolute increase in liters and percentage increase in forced expiratory volume in 1 second (FEV1) obtained with magnesium sulfate application to the increases obtained with placebo after 15, 30, and 45 minutes, no significant differences were found. When we compared absolute and percentage increases in FEV1 after administering salbutamol, we found significantly greater increases after magnesium sulfate administration. The mean (SD) absolute increase in FEV1 was 0.185 (0.42) L after magnesium sulfate administration and 0.081 (0.01) L after placebo (P=.004). The percentage increase in FEV1 was 17.11% (3.7%) after magnesium sulfate and 7.06% (1.8%) after placebo (P=.008). Conclusions Intravenous administration of magnesium sulfate has no bronchodilating effect in patients with COPD exacerbations. It does, however, enhance the bronchodilating effect of inhaled β2-agonists.
- Subjects :
- Spirometry
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
medicine.drug_class
Placebo-controlled study
Pulmonary disease
Bronchi
Ipratropium bromide
Placebo
Magnesium Sulfate
Pulmonary Disease, Chronic Obstructive
Double-Blind Method
Bronchodilator
medicine
Humans
Infusions, Intravenous
Asthma
COPD
medicine.diagnostic_test
business.industry
General Medicine
Middle Aged
medicine.disease
respiratory tract diseases
Bronchodilator Agents
Surgery
Hospitalization
Anesthesia
Acute Disease
Salbutamol
business
Intravenous magnesium
medicine.drug
Subjects
Details
- ISSN :
- 17450454
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Respiratory Medicine: COPD Update
- Accession number :
- edsair.doi.dedup.....39c68852933009e9cc47594ff7cfcb22
- Full Text :
- https://doi.org/10.1016/j.rmedu.2006.09.030