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Efficacy and safety of adding evogliptin versus sitagliptin for metformin-treated patients with type 2 diabetes: A 24-week randomized, controlled trial with open label extension
- Source :
- Diabetes, Obesity & Metabolism
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Aims This trial consisted of a 24-week multicenter, randomised, double-blind, double-dummy, active-controlled study and a 52-week open label extension study to assess the efficacy and safety of evogliptin, a novel dipeptidyl peptidase-4 inhibitor, compared to sitagliptin in patients with type 2 diabetes who have inadequate glycaemic control with metformin alone. Materials and Methods Adult type 2 diabetes mellitus patients (N = 222) with HbA1c 6.5–11% on stable metformin doses (≥1000 mg/day) were randomised 1:1 to add-on 5 mg evogliptin (N = 112) or 100 mg sitagliptin (N = 110) once daily for 24 weeks. The primary efficacy analysis consisted of a comparison of the change from baseline HbA1c at week 24. Non-inferiority was concluded if the upper limit of the two-sided 95% confidence interval for the HbA1c difference between the treatments was
- Subjects :
- Male
endocrine system diseases
type 2 diabetes mellitus
Endocrinology, Diabetes and Metabolism
Drug Resistance
Type 2 diabetes
030204 cardiovascular system & hematology
Pharmacology
Piperazines
combination therapy
law.invention
0302 clinical medicine
Endocrinology
Randomized controlled trial
law
Evogliptin
Incidence
DPP‐4 inhibitor
Middle Aged
Metformin
Sitagliptin
Original Article
Drug Therapy, Combination
Female
Drug Monitoring
medicine.drug
medicine.medical_specialty
030209 endocrinology & metabolism
sitagliptin
03 medical and health sciences
Internal medicine
Diabetes mellitus
Republic of Korea
Internal Medicine
medicine
Humans
Hypoglycemic Agents
Adverse effect
Aged
Glycated Hemoglobin
Dipeptidyl-Peptidase IV Inhibitors
business.industry
Sitagliptin Phosphate
Type 2 Diabetes Mellitus
Original Articles
medicine.disease
Hypoglycemia
Diabetes Mellitus, Type 2
evogliptin
Hyperglycemia
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 14628902
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Diabetes, Obesity and Metabolism
- Accession number :
- edsair.doi.dedup.....39b255710bb38a07e7c6822c68876ad7