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Antimicrobial and cytotoxic constituents from native Cameroonian medicinal plant Hypericum riparium
- Source :
- Fitoterapia. 102:149-155
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Bioassay guided fractionation of Hypericum riparium leaves extract has resulted in the isolation and characterization of three new compounds namely chipericumin E (1), hyperenone C (3), and hyperixanthone (5), together with twenty known compounds. Their structures were elucidated based on comprehensive interpretation of spectroscopic and spectrometric data. Compounds 1-4, and 6-8 displayed moderate antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and cytotoxic effects on the human gastric cell line BGC-823 with IC50 values ranging from 6.54 to 18.50μM.
- Subjects :
- Methicillin-Resistant Staphylococcus aureus
Bioassay guided fractionation
Xanthones
medicine.disease_cause
Lactones
Cell Line, Tumor
Drug Discovery
Botany
medicine
Humans
Cytotoxic T cell
Spiro Compounds
Butenolide
Pharmacology
Plants, Medicinal
Molecular Structure
biology
Traditional medicine
Plant Extracts
Chemistry
General Medicine
Antimicrobial
biology.organism_classification
Antineoplastic Agents, Phytogenic
Methicillin-resistant Staphylococcus aureus
Anti-Bacterial Agents
Plant Leaves
Staphylococcus aureus
Hypericum
Antibacterial activity
Subjects
Details
- ISSN :
- 0367326X
- Volume :
- 102
- Database :
- OpenAIRE
- Journal :
- Fitoterapia
- Accession number :
- edsair.doi.dedup.....39ab8bc38d4d38660c2dc7c59d037dde