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Impact of blinking on ocular surface and tear film parameters
- Source :
- The Ocular Surface. 16:424-429
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- To investigate the influence of blinking on tear film parameters, ocular surface characteristics, and dry eye symptomology.A total of 154 participants were recruited in an age, gender and ethnicity-matched cross-sectional study, of which 77 exhibited clinically detectable incomplete blinking, and 77 did not. Blink rate, dry eye symptomology, tear film parameters, and ocular surface characteristics were assessed in a single clinical session.Overall, a higher proportion of participants exhibiting incomplete blinking fulfilled the TFOS DEWS II dry eye diagnostic criteria (64% versus 44%, p = 0.02), with an odds ratio (95% CI) of 2.2 (1.2-4.2) times. Participants exhibiting incomplete blinking had higher Ocular Surface Disease Index scores (18 ± 13 versus 12 ± 9, p = 0.01), and greater levels of meibomian gland dropout (41.3 ± 15.7% versus 27.5 ± 14.1%, p 0.001). Furthermore, poorer tear film lipid layer thickness, non-invasive tear film stability, expressed meibum quality, eyelid notching, and anterior blepharitis grades were also observed in those exhibiting incomplete blinking (all p 0.05). Blink frequency did not correlate significantly with any ocular surface parameters (all p 0.05).Incomplete blinking was associated with a two-fold increased risk of dry eye disease. The greater levels of meibomian gland dropout, as well as poorer expressed meibum quality and tear film lipid layer thickness, observed would suggest that incomplete blinking may predispose towards the development of evaporative dry eye.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
genetic structures
Meibomian gland
Cornea
03 medical and health sciences
0302 clinical medicine
Ophthalmology
Odds Ratio
medicine
Humans
Ocular Surface Disease Index
Aged
Blepharitis
Blinking
business.industry
Meibomian Glands
Middle Aged
Lipids
eye diseases
Cross-Sectional Studies
030104 developmental biology
medicine.anatomical_structure
Increased risk
Tears
030221 ophthalmology & optometry
Dry Eye Syndromes
Female
sense organs
Eyelid
business
Conjunctiva
Ocular surface
Subjects
Details
- ISSN :
- 15420124
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- The Ocular Surface
- Accession number :
- edsair.doi.dedup.....399bab1a89e36fd94f49b4180e4c1d79