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Amides from Piper as a Diuretic: Behind the Ethnopharmacological Uses of Piper glabratum Kunth
- Source :
- Evidence-Based Complementary and Alternative Medicine, Vol 2014 (2014), Evidence-based Complementary and Alternative Medicine : eCAM
- Publication Year :
- 2014
- Publisher :
- Hindawi Limited, 2014.
-
Abstract
- Several species of the genusPiperare known in Brazilian folk medicine as having diuretic activity. So, we propose to investigate the acute diuretic activity and the possible toxic effects ofPiper glabratumKunth, popularly known as false Jaborandi. Additionally, we propose to check whether there is any correlation between the biological activities of the crude extract (MEPG) and its 2-methoxy-4,5-methylenedioxy-trans-cinnamoyl-pyrrolidine (MMCP) in Wistar rats. The MEPG was fractioned by chromatography column and the MMCP was identified by analyses of1H and13C RMN spectral data and correlations. Both MEPG and MMCP were assayed for diuretic activity. The preparations obtained were orally administered in a single dose to rats. The urine excretion, pH, density, conductivity, and content of Na+, K+, Cl−, andHCO3-were measured in the urine of saline-loaded animals. Additionally, acute toxicity of the extract was also evaluated. MMCP at doses of 30 mg/kg was able to increase the urine volume, pH, andHCO3-excretion. Moreover, high dosage of MEPG showed important liver toxicity and elevated mortality when injected intraperitoneally. The results indicate that the MMCP shows important diuretic properties when administered in Wistar rats. Additionally, MEPG can induce important acute toxicity if given in high doses.
- Subjects :
- Piper
biology
Traditional medicine
Article Subject
business.industry
medicine.medical_treatment
Piper glabratum
Urine
lcsh:Other systems of medicine
Pharmacology
biology.organism_classification
lcsh:RZ201-999
Acute toxicity
Excretion
Complementary and alternative medicine
parasitic diseases
High doses
Medicine
Diuretic
business
Chromatography column
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 17414288
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- Evidence-Based Complementary and Alternative Medicine
- Accession number :
- edsair.doi.dedup.....399b7395fdc2e4cd29024e1f379c4ab2