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A Case of Acute Motor Sensory Axonal Neuropathy: A Variant of Guillain-Barré Syndrome, with Possible Syndrome of Irreversible Lithium-Effectuated Neurotoxicity
- Source :
- Case Reports in Medicine, Case Reports in Medicine, Vol 2020 (2020)
- Publication Year :
- 2020
- Publisher :
- Hindawi, 2020.
-
Abstract
- Acute Motor Sensory Axonal Neuropathy (AMSAN) is a rare and severe variant of Guillain-Barré syndrome (GBS) that has a prolonged recovery course. GBS is often suspected due to ascending muscle weakness, sensation difficulties, respiratory compromise, and antecedent diarrhea. The diagnosis of GBS is supported by cerebrospinal fluid analysis showing albuminocytologic dissociation. Electromyogram and nerve conduction study confirm the diagnosis and allow for further classification by variant. Treatment involves either IV immune globulins or plasmapheresis, and patients typically recover. However, depending on the variant and severity, patients may ultimately require prolonged mechanical ventilation with tracheostomy. In these cases, they may continue to have persistent muscle and sensation abnormalities requiring long-term care. We present a unique case of a 38-year-old female patient with decade-long use of lithium for bipolar disorder that presented with acute lithium toxicity. Though she was ultimately diagnosed with AMSAN, the Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) may have also contributed to her persistent neurological sequelae.
- Subjects :
- Acute motor sensory axonal neuropathy
Mechanical ventilation
medicine.diagnostic_test
Lithium (medication)
Guillain-Barre syndrome
business.industry
medicine.medical_treatment
Muscle weakness
Case Report
General Medicine
medicine.disease
03 medical and health sciences
0302 clinical medicine
Anesthesia
Nerve conduction study
Medicine
Plasmapheresis
030212 general & internal medicine
Bipolar disorder
medicine.symptom
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 16879635 and 16879627
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- Case Reports in Medicine
- Accession number :
- edsair.doi.dedup.....3988dc5d409fbe37a97b6f9fcc581eff