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Gene Polymorphisms of Interleukin-10 and Tumor Necrosis Factor-α Are Associated with Contrast-Induced Nephropathy
- Source :
- American Journal of Nephrology. 37:110-117
- Publication Year :
- 2013
- Publisher :
- S. Karger AG, 2013.
-
Abstract
- Background/Aims: Contrast-induced nephropathy (CIN) is the third most common cause of hospital-acquired acute renal failure. However, the pathogenesis of CIN remains unclear. This study evaluated the role of anti-inflammatory cytokine interleukin-10 (IL-10) and pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) gene polymorphisms as CIN susceptibility markers after percutaneous coronary intervention (PCI). Methods: Four IL-10 tag SNPs (rs1554286, rs3021094, rs3790622, rs1800896) and three TNF-α tag SNPs (rs1799964, rs1800630, rs1800629) were analyzed by MALDI-TOF mass spectrometry in 53 CIN patients and 455 control subjects. Serum IL-10 and TNF-α were detected using ELISA. Results: When compared to controls, the CIN patients showed increased frequencies of CC (rs1554286) and AG+GG (rs1800896) genotypes in IL-10 and GA+AA (rs1800629) genotype in TNF-α (OR = 2.24 (1.13–4.44), p = 0.018; OR = 2.61 (1.30–5.26), p = 0.005, and OR = 2.11 (1.08–4.09), p = 0.025, respectively). Baseline serum IL-10 levels in CIN patients were significantly lower (1.02 ± 1.14 vs. 2.78 ± 4.73 pg/ml, p = 0.008). Patients with CIN had a higher rate of decline in renal function than those without CIN (0.89 ± 1.67 vs. 0.30 ± 0.95 ml/min/1.73 m2 per month, p = 0.002). Significantly higher rates of decline in creatinine clearance were noted in patients with TNF-α (rs1800629) GA+AA than GG genotype (0.88 ± 1.83 vs. 0.36 ± 0.70, p = 0.03), and with IL-10 (rs1800896) AG+GG than AA genotype (1.28 ± 2.14 vs. 0.33 ± 0.90, p < 0.001). Conclusions: Gene polymorphisms of IL-10 and TNF-α are associated with CIN risk and long-term renal outcome after PCI. More prospective studies are needed to confirm our results.
- Subjects :
- Male
Pathology
medicine.medical_specialty
medicine.medical_treatment
Contrast-induced nephropathy
Contrast Media
Inflammation
urologic and male genital diseases
Polymorphism, Single Nucleotide
Nephropathy
Pathogenesis
Percutaneous Coronary Intervention
Text mining
Gene Frequency
Confidence Intervals
Odds Ratio
medicine
Humans
Prospective Studies
neoplasms
Aged
Aged, 80 and over
Analysis of Variance
Tumor Necrosis Factor-alpha
business.industry
Acute kidney injury
virus diseases
Percutaneous coronary intervention
Acute Kidney Injury
Middle Aged
medicine.disease
female genital diseases and pregnancy complications
Interleukin-10
Interleukin 10
surgical procedures, operative
Nephrology
Case-Control Studies
Creatinine
Female
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 14219670 and 02508095
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- American Journal of Nephrology
- Accession number :
- edsair.doi.dedup.....397baac0c539c4a51ea48d050741c8b0