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Gomisin N from Schisandra chinensis Ameliorates Lipid Accumulation and Induces a Brown Fat-Like Phenotype through AMP-Activated Protein Kinase in 3T3-L1 Adipocytes
- Source :
- International Journal of Molecular Sciences, Vol 21, Iss 6, p 2153 (2020), International Journal of Molecular Sciences, Volume 21, Issue 6
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Obesity results from an imbalance between energy intake and energy expenditure, in which excess fat is stored as triglycerides (TGs) in white adipocytes. Recent studies have explored the anti-obesity effects of certain edible phytochemicals, which suppress TG accumulation and stimulate a brown adipocyte-like phenotype in white adipocytes. Gomisin N (GN) is an important bioactive component of Schisandra chinensis, a woody plant endemic to Asia. GN has antioxidant, anti-inflammatory and hepatoprotective effects in vivo and in vitro. However, the anti-obesity effects of GN in lipid metabolism and adipocyte browning have not yet been investigated. In the present study, we aimed to determine whether GN suppresses lipid accumulation and regulates energy metabolism, potentially via AMP-activated protein kinase (AMPK), in 3T3-L1 adipocytes. Our findings demonstrate that GN inhibited adipogenesis and lipogenesis in adipocyte differentiation. Also, GN not only increased the expression of thermogenic factors, including uncoupling protein 1 (UCP1), but also enhanced fatty acid oxidation (FAO) in 3T3-L1 cells. Therefore, GN may have a therapeutic benefit as a promising natural agent to combat obesity.
- Subjects :
- medicine.medical_specialty
obesity
Schisandra chinensis
Catalysis
Inorganic Chemistry
lcsh:Chemistry
chemistry.chemical_compound
3t3-l1
AMP-activated protein kinase
Adipocyte
Internal medicine
medicine
Physical and Theoretical Chemistry
Protein kinase A
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
browning
gomisin n
biology
lipid accumulation
Organic Chemistry
Lipid metabolism
3T3-L1
General Medicine
biology.organism_classification
Computer Science Applications
Endocrinology
chemistry
lcsh:Biology (General)
lcsh:QD1-999
Adipogenesis
Lipogenesis
biology.protein
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 21
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....397861a81812d3310fb839d4f841322e