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Performance of procalcitonin in diagnosing parapneumonic pleural effusions
- Source :
- Medicine
- Publication Year :
- 2017
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2017.
-
Abstract
- Background: Parapneumonic pleural effusion (PPE) is a common complication of pneumonia. The accurate diagnosis of PPE remains a challenge. Recent studies suggest that procalcitonin (PCT) emerges as a potential biomarker for PPE. Our study aimed to determine the diagnostic value of PCT for PPE by a clinical study and summarize the overall diagnostic performance of PCT through a meta-analysis. Methods: Demographic and clinical data of the patients with PPE and controls were collected in our clinical study. The diagnostic performances of serum PCT (s-PCT) were analyzed via receiver operating characteristic (ROC) curve analysis, using area under the curve (AUC) as a measure of accuracy. Literature databases were systematically searched for the studies examining the accuracy of PCT for diagnosing PPE. Data on sensitivity, specificity, positive/negative likelihood ratio (PLR/NLR), and diagnostic odds ratio (DOR) were pooled. Summary ROC curves and AUC were used to evaluate overall test performance. Results: In our clinical study, 47 patients with PPE and 101 controls were included. The s-PCT levels were significantly increased in the setting of PPE (5.44 ± 9.82 ng/mL) compared with malignant PE (0.15 ± 0.19 ng/mL), tuberculous PE (0.18 ± 0.16 ng/mL), and transudates (0.09 ± 0.03 ng/mL) (P
- Subjects :
- Adult
Blood Glucose
Calcitonin
Male
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
diagnosis
Pleural effusion
Sensitivity and Specificity
parapneumonic pleural effusion
Procalcitonin
Clinical study
03 medical and health sciences
0302 clinical medicine
parasitic diseases
medicine
Humans
030212 general & internal medicine
Intensive care medicine
Aged
business.industry
General Medicine
Middle Aged
bacterial infections and mycoses
medicine.disease
respiratory tract diseases
Pleural Effusion
meta-analysis
Pneumonia
ROC Curve
030228 respiratory system
Potential biomarkers
Meta-analysis
Female
Complication
business
Biomarkers
Systematic Review and Meta-Analysis
procalcitonin
hormones, hormone substitutes, and hormone antagonists
Research Article
Subjects
Details
- ISSN :
- 00257974
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....3977fb14aaf3f06e1b354179e7f4002f