Supplemental figures S1-9 from Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin

Figure S1. Components of EnCore-A; Figure S2. Silencing of CTNNB1 mRNA after single-dose or multiple-dose regimens; Figure S3: Comparable activity achieved with a payload with 2'F modifications; Figure S4. Tumor growth inhibition in multiple subcutaneous xenograft models; Figure S5. No efficacy observed in APC/CTNNB1 wild-type RKO tumors; Figure S6. ApoE-independent DsiRNA delivery to primary and metastatic tumors; Figure S7. Detection of cleaved CTNNB1 mRNA by 5'RACE-Seq; Figure S8. EnCore-mediated delivery to CTNNB1/YAP-driven hepatoblastoma; Figure S9: Tolerability profile of EnCore-R/CTNNB1 DsiRNA in nonhuman primates.