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Doppler indexes of left ventricular systolic and diastolic flow and central pulse pressure in relation to renal resistive index
- Source :
- American Journal of Hypertension, 28(4), 535-545. Oxford University Press
- Publication Year :
- 2014
-
Abstract
- BACKGROUND The cardio-renal interaction occurs via hemodynamic and humoral factors. Noninvasive assessment of renal hemodynamics is currently possible by assessment of renal resistive index (RRI) derived from intrarenal Doppler arterial waveforms as ((peak systolic velocity - end-diastolic velocity)/peak systolic velocity). Limited information is available regarding the relationship between RRI and cardiac hemodynamics. We investigated these associations in randomly recruited subjects from a general population. METHODS In 171 participants (48.5% women; mean age, 52.2 years), using pulsed wave Doppler, we measured RRI (mean, 0.60) and left ventricular outflow tract (LVOT) and transmitral (E and A) blood flow peak velocities and its velocity time integrals (VTI). Using carotid applanation tonometry, we measured central pulse pressure and arterial stiffness indexes such as augmentation pressure and carotid-femoral pulse wave velocity. RESULTS In stepwise regression analysis, RRI independently and significantly increased with female sex, age, body weight, brachial pulse pressure, and use of β-blockers, whereas it decreased with body height and mean arterial pressure. In multivariable-adjusted models with central pulse pressure and arterial stiffness indexes as the explanatory variables, we observed a significant and positive correlation of RRI only with central pulse pressure (P < 0.0001). Among the Doppler indexes of left ventricular blood flow, RRI was significantly and positively associated with LVOT and E peak velocities (P ≤ 0.012) and VTIs (P ≤ 0.010). CONCLUSIONS We demonstrated that in unselected subjects RRI was significantly associated with central pulse pressure and left ventricular systolic and diastolic Doppler blood flow indexes. Our findings imply that in addition to the anthropometric characteristics, cardiac hemodynamic factors influence the intrarenal arterial Doppler waveform patterns.
- Subjects :
- Adult
Male
Mean arterial pressure
medicine.medical_specialty
Manometry
Systole
Hemodynamics
Blood Pressure
030204 cardiovascular system & hematology
Pulse Wave Analysis
Kidney
Ventricular Function, Left
Renal Circulation
03 medical and health sciences
0302 clinical medicine
Vascular Stiffness
Belgium
Diastole
Predictive Value of Tests
Risk Factors
Internal medicine
Internal Medicine
medicine
Humans
030212 general & internal medicine
Longitudinal Studies
Ultrasonography, Doppler, Color
Pulse wave velocity
Aged
Echocardiography, Doppler, Pulsed
Chi-Square Distribution
business.industry
Blood flow
Middle Aged
medicine.disease
Pulse pressure
Blood pressure
Hypertension
Multivariate Analysis
cardiovascular system
Cardiology
Arterial stiffness
Linear Models
Female
Vascular Resistance
business
Blood Flow Velocity
Subjects
Details
- ISSN :
- 19417225 and 08957061
- Volume :
- 28
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- American journal of hypertension
- Accession number :
- edsair.doi.dedup.....3958dfd0edb1187f0f3c7e0bfc1f9b60