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Gravity-Induced Lower-Leg Swelling Can Be Ameliorated by Ingestion of α-Glucosyl Hesperidin Beverage
- Source :
- Frontiers in Physiology, Frontiers in Physiology, Vol 12 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- The most likely cause of lower-leg swelling is prolonged sitting, which sometimes induces deep vein thrombosis, also known as, economy class syndrome. We aimed to clarify the influence of intake of 4G-α-glucopyranosyl hesperidin (G-Hsp) beverage on the lower-leg swelling caused by 6 h of sitting in six healthy women. All subjects ingested 100 mL of G-Hsp or Placebo beverages with 100 mL of mineral water after 10 min of rest in a chair. Subsequently, subjects were requested to sit in the chair in a relaxed position for 6 h with two breaks to walk for urination. Calf water content measured by impedance plethysmography, calf circumference, and calf skin temperature by infrared thermography were measured, along with assessment of calf swelling sensation on a visual analog scale. Increase in ankle % circumference was significantly less after the G-Hsp ingestion (101.8 ± 1.5%) than after placebo (103.3 ± 0.8%; P = 0.004). A significant difference was found between percent circumference after the G-Hsp and the placebo, that is, the calf swelling after the placebo was significantly larger (P = 0.043). A gradual increase in skin temperature at the lower limb was observed after G-Hsp ingestion, while there was no change after placebo. Gravity-induced calf and ankle swelling resulted by prolonged sitting can be ameliorated by oral ingestion of hesperidin-derived G-Hsp through production of nitric oxide. It might be helpful in preventing economy-class syndrome caused by enforced sitting for a long duration.
- Subjects :
- 0106 biological sciences
0301 basic medicine
Visual analogue scale
Physiology
media_common.quotation_subject
Placebo
Sitting
01 natural sciences
Urination
03 medical and health sciences
skin surface temperature
010608 biotechnology
Physiology (medical)
medicine
Plethysmograph
Ingestion
QP1-981
4G-α-glucopyranosyl hesperidin
vascular permeability
media_common
Original Research
030109 nutrition & dietetics
business.industry
gravity
medicine.anatomical_structure
Anesthesia
lower leg swelling
Ankle
Swelling
medicine.symptom
business
Subjects
Details
- Language :
- English
- ISSN :
- 1664042X
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Physiology
- Accession number :
- edsair.doi.dedup.....39569fd3165ad4a794c72fad04fe9946