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Repeated lumbar punctures within 3 days may affect CSF biomarker levels
- Source :
- Fluids and Barriers of the CNS, Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-5 (2019)
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Lumbar puncture (LP) is a common way of collecting cerebrospinal fluid (CSF) both in the clinic and in research. In this extension of a study on the relationship between sleep deprivation and CSF biomarkers for Alzheimer’s disease, we investigated CSF biomarker dynamics in relation to rebound sleep after sleep deprivation. Two LPs were performed within 3 days in 13 healthy volunteers. We noticed an unexpected sharp rise in biomarker concentrations in the second sample and therefore repeated the experiment, but without sleep intervention, in four additional individuals. The findings were similar in these subjects, suggesting an inherent methodological problem with repeated LPs. The result corroborates findings in studies with repeated CSF collection via indwelling lumbar catheters, and needs to be addressed in, for instance, pharmacodynamic studies employing these techniques.
- Subjects :
- Adult
Male
0301 basic medicine
Neurofilament light
medicine.medical_specialty
YKL-40
GFAp
Spinal Puncture
lcsh:RC346-429
Young Adult
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Cerebrospinal fluid
Lumbar
Developmental Neuroscience
Alzheimer Disease
Internal medicine
Lumbar puncture
Humans
Short Paper
Medicine
lcsh:Neurology. Diseases of the nervous system
Hematology
medicine.diagnostic_test
business.industry
Amyloid β
General Medicine
Sleep in non-human animals
3. Good health
Sleep deprivation
030104 developmental biology
Neurology
Pharmacodynamics
Anesthesia
Sleep Deprivation
Biomarker (medicine)
Female
Tau
medicine.symptom
business
Alzheimer’s disease
Biomarkers
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 20458118
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Fluids and Barriers of the CNS
- Accession number :
- edsair.doi.dedup.....3943f2744a0c49fb83a5bb9820606473