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Cardiovascular disease burden in adult patients with cancer: An 11-year nationwide population-based cohort study
- Source :
- International Journal of Cardiology. 317:167-173
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Background Cardiovascular disease (CVD) is an important cause of morbidity and mortality in patients with cancer. However, the real-world CVD burden of adult cancer patients has not been well established. This study aimed to evaluate the prevalence and mortality of pre-existing and new-onset CVD in patients with cancers. Methods We analysed the prevalence and mortality of pre-existing and new-onset CVD in 41,034 adult patients with ten common solid cancers in a single payer system using data from the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Results When all types of cancer were included, 11.3% (n = 4647) of patients had pre-existing CVD when they were diagnosed with cancer. After excluding patients with pre-existing CVD, 15.7% of cancer patients (n = 5703) were newly diagnosed with CVD during the follow-up period (median 68 months). Both pre-existing and new-onset CVD were associated with increased risk of overall mortality and 5-year mortality. Multivariate analysis to predict all-cause mortality indicated both pre-existing and new-onset CVD, male sex, old age, prior history of diabetes or chronic kidney disease, suburban residential area, and low-income status as significant factors. Conclusions Eleven percent of cancer patients had pre-existing CVD at the time of cancer diagnosis, and about 16% of cancer patients without pre-existing CVD were newly diagnosed with CVD, mostly within 5 years after the cancer diagnosis. Proper management of pre-existing CVD is necessary and pre-emptive prevention of new-onset CVD may alter treatment options and outcomes.
- Subjects :
- Adult
Male
medicine.medical_specialty
Multivariate analysis
Disease
030204 cardiovascular system & hematology
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Risk Factors
Neoplasms
Internal medicine
Diabetes mellitus
Diabetes Mellitus
Prevalence
medicine
Humans
cardiovascular diseases
030212 general & internal medicine
Disease burden
Adult patients
business.industry
Cancer
medicine.disease
Cardiovascular Diseases
Cohort
Cardiology and Cardiovascular Medicine
business
Kidney disease
Subjects
Details
- ISSN :
- 01675273
- Volume :
- 317
- Database :
- OpenAIRE
- Journal :
- International Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....39413cf0b15f2f8c1ac7847f91614f8b