A lignin glycoside and a nortriterpenoid from Kadsura coccinea

Aim To study the chemical constituents of the roots and stem bark of Kadsura coccinea . Method Compounds were isolated by column chromatography on silica gel and Sephadex LH-20, and finally purified by prep-HPLC. Their structures were elucidated by extensive spectroscopic methods, including 1D- and 2D-NMR, and HR-ESI-MS. Results Two compounds were determined as (7′ S ,8′ S ,8 R )-(8β,8′α)-dimethyl-4,4′-dihydroxy-5,3′-dimethoxy-5′-cyclolignan glucoside ( 1 ) and micrandiactone H ( 2 ), respectively. Conclusion Compunds 1 and 2 are new and neither showed inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-induced RAW264.7 macrophages.