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Convergent Evolution of Mucosal Immune Responses at the Buccal Cavity of Teleost Fish
- Source :
- iScience, Vol 19, Iss, Pp 821-835 (2019), iScience
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Summary The buccal mucosa (BM) is a critical first line of defense in terrestrial animals. To gain further insights into the evolutionary origins and primordial roles of BM in teleosts here we show that rainbow trout, a teleost fish, contains a diffuse mucosal associated lymphoid tissue (MALT) within its buccal cavity. Upon parasite infection, a fish immunoglobulin specialized in mucosal immunity (sIgT) was induced to a high degree, and parasite-specific sIgT responses were mainly detected in the buccal mucus. Moreover, we show that the trout buccal microbiota is prevalently coated with sIgT. Overall our findings revealed that the MALT is present in the BM of a non-tetrapod species. As fish IgT and mucus-producing cells are evolutionarily unrelated to mammalian IgA and salivary glands, respectively, our findings indicate that mucosal immune responses in the BM of teleost fish and tetrapods evolved through a process of convergent evolution.<br />Graphical Abstract<br />Highlights • A mucosal associated lymphoid tissue is identified in teleost buccal cavity • Local immune responses can be induced in teleost buccal mucosa • Teleost IgT plays important roles in defending against buccal pathogen • Microbiota in teleost buccal mucosa is prevalently coated with secreted IgT<br />Biological Sciences; Immunology; Omics; Transcriptomics
- Subjects :
- 0301 basic medicine
endocrine system
Immunology
Omics
02 engineering and technology
Article
Microbiology
Transcriptome
03 medical and health sciences
stomatognathic system
Parasite hosting
14. Life underwater
Transcriptomics
lcsh:Science
Multidisciplinary
biology
Buccal administration
Biological Sciences
021001 nanoscience & nanotechnology
biology.organism_classification
Mucus
3. Good health
Trout
030104 developmental biology
Lymphatic system
biology.protein
Rainbow trout
lcsh:Q
Antibody
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 25890042
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- iScience
- Accession number :
- edsair.doi.dedup.....3933c8efe4bc5c7492c63fe43ccb7052