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Factors associated with abnormal spirometry among HIV-infected individuals
- Source :
- Drummond, MB; Huang, L; Diaz, PT; Kirk, GD; Kleerup, EC; Morris, A; et al.(2015). Factors associated with abnormal spirometry among HIV-infected individuals. AIDS, 29(13), 1691-1700. doi: 10.1097/QAD.0000000000000750. UCSF: Retrieved from: http://www.escholarship.org/uc/item/91f8n727, AIDS (London, England), vol 29, iss 13
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- Author(s): Drummond, M Bradley; Huang, Laurence; Diaz, Philip T; Kirk, Gregory D; Kleerup, Eric C; Morris, Alison; Rom, William; Weiden, Michael D; Zhao, Enxu; Thompson, Bruce; Crothers, Kristina | Abstract: ObjectiveHIV-infected individuals are susceptible to development of chronic lung diseases, but little is known regarding the prevalence and risk factors associated with different spirometric abnormalities in this population. We sought to determine the prevalence, risk factors and performance characteristics of risk factors for spirometric abnormalities among HIV-infected individuals.DesignCross-sectional cohort study.MethodsWe analyzed cross-sectional US data from the NHLBI-funded Lung-HIV consortium - a multicenter observational study of heterogeneous groups of HIV-infected participants in diverse geographic sites. Logistic regression analysis was performed to determine factors statistically significantly associated with spirometry patterns.ResultsA total of 908 HIV-infected individuals were included. The median age of the cohort was 50 years, 78% were men and 68% current smokers. An abnormal spirometry pattern was present in 37% of the cohort: 27% had obstructed and 10% had restricted spirometry patterns. Overall, age, smoking status and intensity, history of Pneumocystis infection, asthma diagnosis and presence of respiratory symptoms were independently associated with an abnormal spirometry pattern. Regardless of the presence of respiratory symptoms, five HIV-infected participants would need to be screened with spirometry to diagnose two individuals with any abnormal spirometry pattern.ConclusionsNearly 40% of a diverse US cohort of HIV-infected individuals had an abnormal spirometry pattern. Specific characteristics including age, smoking status, respiratory infection history and respiratory symptoms can identify those at risk for abnormal spirometry. The high prevalence of abnormal spirometry and the poor predictive capability of respiratory symptoms to identify abnormal spirometry should prompt clinicians to consider screening spirometry in HIV-infected populations.
- Subjects :
- Lung Diseases
Male
lung disease
Cross-sectional study
spirometry
HIV Infections
Logistic regression
Medical and Health Sciences
Cohort Studies
Risk Factors
Prevalence
2.2 Factors relating to the physical environment
Immunology and Allergy
Aetiology
Lung
education.field_of_study
medicine.diagnostic_test
Respiratory infection
Middle Aged
Biological Sciences
Infectious Diseases
Cohort
Respiratory
HIV/AIDS
Female
social and economic factors
Infection
Cohort study
Adult
Spirometry
medicine.medical_specialty
Immunology
Population
Article
respiratory tract disease
Clinical Research
2.3 Psychological
Virology
Internal medicine
medicine
Humans
education
obstructive
Asthma
business.industry
Prevention
Psychology and Cognitive Sciences
HIV
lung function
medicine.disease
United States
Cross-Sectional Studies
Good Health and Well Being
Physical therapy
business
2.4 Surveillance and distribution
Subjects
Details
- ISSN :
- 02699370
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- AIDS
- Accession number :
- edsair.doi.dedup.....3930773822d6d7e4f60a5ec4f523654f
- Full Text :
- https://doi.org/10.1097/qad.0000000000000750