Back to Search
Start Over
Statins and the risk of polyneuropathy: A systematic review and two meta-analyses
- Source :
- MusclenerveREFERENCES. 65(1)
- Publication Year :
- 2021
-
Abstract
- INTRODUCTION/AIMS Previous studies have shown inconsistent data on the relationship between statin use and polyneuropathy (PN). The current systematic review and meta-analyses were conducted to comprehensively investigate the risk of incident PN among statin-users compared with non-users by identifying all available studies and summarizing their results. METHODS A systematic review was conducted from MEDLINE and EMBASE databases from inception to October 31, 2020. We included cohort and case-control studies that compared the risk of incident PN between statin-users and non-users. Point estimates and standard errors from eligible studies were pooled together using the generic inverse variance method. RESULTS Of 4968 retrieved articles, 6 studies in non-diabetic populations and 2 studies in diabetic populations fulfilled the inclusion criteria. Two meta-analyses were performed. The pooled analyses did not find a statistically significant association between the use of statins and risk of incident PN with the pooled odds ratio of 1.24 (95% confidence interval [CI], 0.88-1.76; I2 74%) and 0.82 (95% CI, 0.56-1.21; I2 80%) in non-diabetic and diabetic groups respectively. DISCUSSION No significant association between the use of statins and the risk of PN was observed in this systematic review and these two meta-analyses. However, there was a high degree of heterogeneity of the meta-analyses.
- Subjects :
- Variance method
medicine.medical_specialty
Physiology
business.industry
MEDLINE
Odds ratio
medicine.disease
Confidence interval
Cellular and Molecular Neuroscience
Polyneuropathies
Standard error
Physiology (medical)
Internal medicine
Meta-analysis
Case-Control Studies
Cohort
medicine
Diabetes Mellitus
Odds Ratio
Humans
Neurology (clinical)
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
Polyneuropathy
Subjects
Details
- ISSN :
- 10974598
- Volume :
- 65
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- MusclenerveREFERENCES
- Accession number :
- edsair.doi.dedup.....39297b84ea8a7f9f86f331922d958ab1