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Eprosartan in the Primary Prevention of Cardiac Allograft Vascular Disease: A Double-Blind Prospectively Randomized Study using Intravascular Ultrasound
- Source :
- Journal of International Medical Research. 36:1022-1031
- Publication Year :
- 2008
- Publisher :
- SAGE Publications, 2008.
-
Abstract
- The angiotensin blocker (ARB) eprosartan (600 mg once daily) and the calcium antagonist diltiazem (90 mg twice daily) were studied in a 24-month prospective, randomized, double-blind trial involving 53 heart transplant patients. The study compared their effects on the development of post-transplant cardiac allograft vasculopathy, a condition that frequently impairs long-term post-transplantation survival and where angiotensin blockers might be expected to play a preventive role. From baseline to month 12, the mean plaque volume increased by 7.7 mm3 for eprosartan-treated patients and by 34.4 mm3 for diltiazem-treated patients, but the eprosartan-related trend for reduced myointimal hyperplasia was not statistically significant. The trend in favour of eprosartan for secondary parameters (mean intimal index, vessel volume, lumen volume and coronary flow reserve) also failed to reach significance. The lack of effect might be due to a lower than planned sample size and observation periods due to recruitment difficulties. A larger study is required to confirm these preliminary findings.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Thiophenes
Biochemistry
Double-Blind Method
Internal medicine
Intravascular ultrasound
medicine
Humans
Transplantation, Homologous
Prospective Studies
Vascular Diseases
Diltiazem
Prospective cohort study
Ultrasonography, Interventional
Aged
Heart transplantation
medicine.diagnostic_test
Vascular disease
business.industry
Biochemistry (medical)
Imidazoles
Coronary flow reserve
Eprosartan
Cell Biology
General Medicine
Middle Aged
medicine.disease
Transplantation
Treatment Outcome
Acrylates
Cardiology
Heart Transplantation
Female
business
Angiotensin II Type 1 Receptor Blockers
medicine.drug
Subjects
Details
- ISSN :
- 14732300 and 03000605
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of International Medical Research
- Accession number :
- edsair.doi.dedup.....3923828065cc8ccd552f651cc3cbeb52