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Freeze-dried strawberry and blueberry attenuates diet-induced obesity and insulin resistance in rats by inhibiting adipogenesis and lipogenesis
- Source :
- Foodfunction. 8(11)
- Publication Year :
- 2017
-
Abstract
- Obesity and type 2-diabetes are becoming a worldwide health problem, reiterating the importance of alternative therapies to tackle their progression. Here, we hypothesized that supplementation of diet with 6% w/w of a freeze-dried strawberry–blueberry (5 : 1) powder (FDSB) could exert beneficial metabolic effects on Wistar rats. FDSB-supplemented animals experienced significantly reduced body weight gain, food efficiency and visceral adiposity accumulation in two independent experiments. FDSB supplementation also contributed to lower area under the curve after an intraperitoneal GTT and reduced serum insulin levels and an insulin resistance index (IR-HOMA) in HFS diet-fed animals, together with reduced plasma MCP-1 inflammation marker concentrations. Gene expression analysis in retroperitoneal adipocytes from experiment 1 and 3T3-L1 cells showed that FDSB inhibited adipogenesis and lipogenesis through down-regulation of Pparg, Cebpa, Lep, Fasn, Scd-1 and Lpl gene expression. Untargeted metabolomics identified the cis isomer of resveratrol-3-glucoside-sulphate as a metabolite differentially increased in FDSB-treated serum samples, which corresponds to a strawberry metabolite that could be considered a serum biomarker of FDSB-intake. Our results suggest that FDSB powder might be useful for treatment/prevention of obesity-related diseases.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Peroxisome proliferator-activated receptor gamma
Metabolite
Blueberry Plants
Inflammation
Biology
Diet, High-Fat
Fragaria
03 medical and health sciences
chemistry.chemical_compound
Mice
Insulin resistance
Internal medicine
3T3-L1 Cells
medicine
Adipocytes
Animals
Obesity
Rats, Wistar
030109 nutrition & dietetics
Adipogenesis
CCAAT-Enhancer-Binding Protein-beta
Lipogenesis
Area under the curve
General Medicine
medicine.disease
Rats
PPAR gamma
030104 developmental biology
Endocrinology
chemistry
Anti-Obesity Agents
medicine.symptom
Insulin Resistance
Food Science
Subjects
Details
- ISSN :
- 2042650X
- Volume :
- 8
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Foodfunction
- Accession number :
- edsair.doi.dedup.....39132d680e3d08df6a32e5762e3e768c