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Histopathological findings in fatal COVID-19 severe acute respiratory syndrome: preliminary experience from a series of 10 Spanish patients

Authors :
Borja Recalde-Zamacona
Manuel F. Landecho
Carlota Jordán Iborra
Gema Echarri
Alan Argueta
Laura Alvarez
Javier J. Zulueta
Laura García-Tobar
José Luis del Pozo
Ana Ezponda
M. Alonso
Francisco Carmona Torre
Maria D. Lozano
Carlos E. de Andrea
Jorge Quiroga
Source :
Thorax
Publication Year :
2020
Publisher :
BMJ, 2020.

Abstract

In December 2019, an outbreak of severe acute respiratory syndrome associated to SARS-CoV2 was reported in Wuhan, China. To date, little is known on histopathological findings in patients infected with the new SARS-CoV2. Lung histopathology shows features of acute and organising diffuse alveolar damage. Subtle cellular inflammatory infiltrate has been found in line with the cytokine storm theory. Medium-size vessel thrombi were frequent, but capillary thrombi were not present. Despite the elevation of biochemical markers of cardiac injury, little histopathological damage could be confirmed. Viral RNA from paraffin sections was detected at least in one organ in 90% patients.

Details

ISSN :
14683296 and 00406376
Volume :
75
Database :
OpenAIRE
Journal :
Thorax
Accession number :
edsair.doi.dedup.....38c706f8e8124ec9790bc7e8a0cd5f91
Full Text :
https://doi.org/10.1136/thoraxjnl-2020-215577