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Histopathological findings in fatal COVID-19 severe acute respiratory syndrome: preliminary experience from a series of 10 Spanish patients
- Source :
- Thorax
- Publication Year :
- 2020
- Publisher :
- BMJ, 2020.
-
Abstract
- In December 2019, an outbreak of severe acute respiratory syndrome associated to SARS-CoV2 was reported in Wuhan, China. To date, little is known on histopathological findings in patients infected with the new SARS-CoV2. Lung histopathology shows features of acute and organising diffuse alveolar damage. Subtle cellular inflammatory infiltrate has been found in line with the cytokine storm theory. Medium-size vessel thrombi were frequent, but capillary thrombi were not present. Despite the elevation of biochemical markers of cardiac injury, little histopathological damage could be confirmed. Viral RNA from paraffin sections was detected at least in one organ in 90% patients.
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
Pathology
ARDS
Biopsy
Brief Communication
03 medical and health sciences
0302 clinical medicine
Humans
Medicine
histology/cytology
Respiratory system
Diffuse alveolar damage
Lung
Pandemics
030304 developmental biology
0303 health sciences
medicine.diagnostic_test
SARS-CoV-2
business.industry
COVID-19
Outbreak
imaging/CT MRI etc
medicine.disease
medicine.anatomical_structure
Spain
030220 oncology & carcinogenesis
Histopathology
viral infection
Tomography, X-Ray Computed
business
Cytokine storm
Subjects
Details
- ISSN :
- 14683296 and 00406376
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Thorax
- Accession number :
- edsair.doi.dedup.....38c706f8e8124ec9790bc7e8a0cd5f91
- Full Text :
- https://doi.org/10.1136/thoraxjnl-2020-215577