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Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers
- Source :
- Annals of the Rheumatic Diseases, 69(8), 1548-53. BMJ Publishing Group, Plant, D, Flynn, E, Mbarek, H, Dieudé, P, Cornelis, F, Arlestig, L, Dahlqvist, S R, Goulielmos, G, Boumpas, D T, Sidiropoulos, P, Johansen, J S, Ørnbjerg, L M, Hetland, M L, Klareskog, L, Filer, A, Buckley, C D, Raza, K, Witte, T, Schmidt, R E & Worthington, J 2010, ' Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers ', Annals of the Rheumatic Diseases, vol. 69, no. 8, pp. 1548-53 . https://doi.org/10.1136/ard.2009.121020, Annals of the Rheumatic Diseases
- Publication Year :
- 2010
- Publisher :
- BMJ, 2010.
-
Abstract
- BACKGROUND: Genetic factors have a substantial role in determining development of rheumatoid arthritis (RA), and are likely to account for 50-60% of disease susceptibility. Genome-wide association studies have identified non-human leucocyte antigen RA susceptibility loci which associate with RA with low-to-moderate risk.OBJECTIVES: To investigate recently identified RA susceptibility markers using cohorts from six European countries, and perform a meta-analysis including previously published results.METHODS: 3311 DNA samples were collected from patients from six countries (UK, Germany, France, Greece, Sweden and Denmark). Genotype data or DNA samples for 3709 controls were collected from four countries (not Sweden or Denmark). Eighteen single nucleotide polymorphisms (SNPs) were genotyped using Sequenom MassArray technology. Samples with a >95% success rate and only those SNPs with a genotype success rate of >95% were included in the analysis. Scandinavian patient data were pooled and previously published Swedish control data were accessed as a comparison group. Meta-analysis was used to combine results from this study with all previously published data.RESULTS: After quality control, 3209 patients and 3692 controls were included in the study. Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-analysis. All 18 markers were associated with RA when previously published studies were incorporated in the analysis. Data from this study increased the significance for association with RA and nine markers.CONCLUSIONS: In a large European RA cohort further evidence for the association of 18 markers with RA development has been obtained.
- Subjects :
- Male
Genome-wide association study
Arthritis, Rheumatoid
0302 clinical medicine
Gene Frequency
Rheumatoid
Immunology and Allergy
Non-U.S. Gov't
Basic and Translational Research
0303 health sciences
Research Support, Non-U.S. Gov't
Single Nucleotide
Middle Aged
Connective tissue disease
3. Good health
Multicenter Study
Rheumatoid arthritis
Cohort
Female
Adult
Genetic Markers
medicine.medical_specialty
Genotype
Immunology
Human leukocyte antigen
Research Support
Polymorphism, Single Nucleotide
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
SDG 3 - Good Health and Well-being
Rheumatology
Internal medicine
Journal Article
medicine
Humans
Genetic Predisposition to Disease
Polymorphism
Allele frequency
Aged
030304 developmental biology
030203 arthritis & rheumatology
business.industry
Arthritis
Case-control study
medicine.disease
Case-Control Studies
business
Genome-Wide Association Study
Meta-Analysis
Subjects
Details
- ISSN :
- 00034967
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Annals of the Rheumatic Diseases
- Accession number :
- edsair.doi.dedup.....38c35f422004bb1de15747ad3e60ac00