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Weight gain prior to entry into a weight-loss intervention study among overweight and obese breast cancer survivors
- Source :
- Sedjo, RL; Byers, T; Ganz, PA; Colditz, GA; Demark-Wahnefried, W; Wolin, KY; et al.(2014). Weight gain prior to entry into a weight-loss intervention study among overweight and obese breast cancer survivors. Journal of Cancer Survivorship, 8(3), 410-418. doi: 10.1007/s11764-014-0351-9. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2br0578d, Journal of cancer survivorship : research and practice, vol 8, iss 3, Journal of Cancer Survivorship, vol 8, iss 3, Sedjo, RL; Byers, T; Ganz, PA; Colditz, GA; Demark-Wahnefried, W; Wolin, KY; et al.(2014). Weight gain prior to entry into a weight-loss intervention study among overweight and obese breast cancer survivors. Journal of Cancer Survivorship, 1-9. doi: 10.1007/s11764-014-0351-9. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2m57k555
- Publication Year :
- 2013
-
Abstract
- Purpose: Changes in cancer therapy, in addition to changes in obesity prevalence, suggest the need for a current assessment of weight gain patterns following breast cancer diagnosis. The aim of this study was to evaluate factors associated with weight gain among breast cancer survivors prior to enrolling into a behavioral weight loss intervention. Methods: Anthropometric measures and data on weight-related factors were collected at baseline on 665 breast cancer survivors. Postdiagnosis weight gain was determined between entry into the trial and previous diagnosis up to 5 years. Multivariate logistic regression analyses were used to evaluate the association between weight gain and influencing factors. Results: The mean weight gain was 4.5 % body weight (standard deviation = 10.6); 44 % of women experienced ≥5 % body weight gain. The risk of weight gain was inversely associated with age (adjusted odds ratio (ORadj) = 0.97, 95 % confidence interval (95 % CI) 0.95-0.99), Hispanic ethnicity (ORadj = 0.30, 95 % CI 0.13-0.68), and overweight (ORadj = 0.11, 95 % CI 0.05-0.23) or obese (ORadj = 0.03, 95 % CI 0.02-0.07) status at diagnosis and positively associated with time elapsed since diagnosis (ORadj = 1.19/year, 95 % CI 1.04-1.36). Women prescribed aromatase inhibitors were 46 % less likely to gain weight compared to women prescribed selective estrogen-receptor modulators (ORadj = 0.54, 95 % CI 0.31-0.93). The risk of weight gain was positively associated with smoking at diagnosis (ORadj = 2.69, 95 % CI 1.12-6.49) although this was attributable to women who subsequently quit smoking. Conclusions: Postdiagnosis weight gain is common and complex and influenced by age, ethnicity, weight, smoking status, time elapsed since diagnosis, and endocrine-modulating therapy. Implications for cancer survivors: Weight gain continues to be a concern following a diagnosis of breast cancer. Factors influencing this weight gain include age, ethnicity, weight, smoking status, time elapsed since diagnosis, and endocrine-modulating therapy. Effective weight management strategies are needed for this population of women. © 2014 Springer Science+Business Media New York.
- Subjects :
- Overweight
Cardiovascular
Weight Gain
law.invention
Body Mass Index
Randomized controlled trial
Weight loss
law
Medicine
Survivors
skin and connective tissue diseases
Cancer
Oncology (nursing)
Rehabilitation
Smoking
Hispanic or Latino
Middle Aged
Stroke
Oncology
Public Health and Health Services
Female
medicine.symptom
Hispanic Americans
Adult
medicine.medical_specialty
Clinical Trials and Supportive Activities
Oncology and Carcinogenesis
Breast Neoplasms
Article
Breast cancer
Clinical Research
Intervention (counseling)
Internal medicine
Breast Cancer
Weight Loss
Humans
Women
Oncology & Carcinogenesis
Obesity
Nutrition
Aged
business.industry
Prevention
Breast cancer survivors
medicine.disease
Estrogen
Logistic Models
Physical therapy
sense organs
business
Body mass index
Weight gain
Subjects
Details
- ISSN :
- 19322267
- Volume :
- 8
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of cancer survivorship : research and practice
- Accession number :
- edsair.doi.dedup.....38b92468f87b0b7fc6f17ef3760787cc