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Repeatability and Reproducibility of Choroidal Vessel Layer Measurements in Diabetic Retinopathy Using Enhanced Depth Optical Coherence Tomography
- Source :
- Investigative Opthalmology & Visual Science. 54:2893
- Publication Year :
- 2013
- Publisher :
- Association for Research in Vision and Ophthalmology (ARVO), 2013.
-
Abstract
- Purpose To describe novel segmentation protocols for choroidal layers, Sattler's medium and Haller's large vessel layers, using enhanced depth imaging optical coherence tomography (EDI-OCT), and to examine the repeatability and reproducibility of these measurements in eyes with diabetic retinopathy. Methods Fifty-one patients with Type 2 diabetes mellitus were imaged using custom EDI scanning protocols. Detailed segmentation was performed to quantify the retina, choroid, Haller's large, and Sattler's medium vessel layers in the total macular circle (TMC) and foveal central subfield (FCS). The coefficient of repeatability (CR) and intraclass correlation coefficient (ICC) were used as a measure of repeatability and relative reliability within graders. Reproducibility or interobserver variability was assessed using Bland-Altman plots and 95% limits of agreement (LoA). Results Intragrader CR of the retina, choroid, Sattler's, and Haller's layers for thickness measurements were 19.2, 26.9, 35.2, and 29.2 μm, respectively. Intergrader 95% LoA were 27.9, 41.5, 38.6, 31.1 μm (thickness), respectively. Choroidal sublayer measurements showed good intraobserver reliability (ICC 0.78-0.98). Interobserver variability for retinal and choroidal measurements was not significantly different (P > 0.45). Measurements from the TMC showed slightly better repeatability and agreement compared with the FCS alone. Mean intergrader differences were reduced after training, and were most apparent in choroidal sublayers. Conclusions The choroidal vascular sublayers can be quantified with good reliability, repeatability, and reproducibility. Accurate quantitative assessment of these sublayers may provide new insights into the role of the choroid in visual loss in patients with diabetic retinopathy, and prove useful for future clinical trials.
- Subjects :
- Adult
Male
Fovea Centralis
medicine.medical_specialty
Materials science
genetic structures
Intraclass correlation
Optical coherence tomography
Ophthalmology
medicine
Humans
Aged
Retrospective Studies
Aged, 80 and over
Observer Variation
Reproducibility
Retina
Diabetic Retinopathy
medicine.diagnostic_test
Choroid
Reproducibility of Results
Choroid Diseases
Repeatability
Diabetic retinopathy
Middle Aged
medicine.disease
eye diseases
medicine.anatomical_structure
Diabetes Mellitus, Type 2
Optometry
Female
sense organs
Tomography
Tomography, Optical Coherence
Subjects
Details
- ISSN :
- 15525783
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Investigative Opthalmology & Visual Science
- Accession number :
- edsair.doi.dedup.....38b5c7b80b50a1b04d0212bcad9db108