Immunoregulatory cytokine polymorphisms in Italian patients affected by paroxysmal nocturnal haemoglobinuria and aplastic anaemia

Authors :: Elisa Fermo
Carla Boschetti
Fiorella Alfinito
Wilma Barcellini
Paola Pedotti
Paola Bianchi
Alberto Zanella
Agostino Cortelezzi
Fermo, E
Bianchi, P
Barcellini, W
Pedotti, P
Boschetti, C
Alfinito, Fiorella
Cortelezzi, A
Zanella, A.
Publication Year :: 2004
Publisher :: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036 -Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205, 2004.
Abstract: We investigated regulatory variants of five cytokine genes [tumour necrosis factor (TNF)-alpha, interferon (IFN)-gamma, transforming growth factor (TGF)-beta, interleukin (IL)-6 and IL-10] in 40 Italian patients affected by paroxysmal nocturnal haemoglobinuria (PNH) and aplastic anaemia (AA). Genotypes associated with high production of TGF-beta and IFN-gamma were more frequent in patients than in controls. Genetic regulation of the immunological pathways involved in the pathogenesis of bone marrow failure is suggested.

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