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Correlation of biological parameters with placental parameters and pregnancy outcomes in pre-eclamptic women
- Source :
- Pregnancy Hypertension, Pregnancy Hypertension, 2020, 19, pp.61-66. ⟨10.1016/j.preghy.2019.12.008⟩
- Publication Year :
- 2019
-
Abstract
- Introduction Pre-eclampsia is characterized by maternal vascular malperfusion and chronic inflammation in placenta. Our purpose was to investigate the potential correlation of biological parameters with placental parameters and pregnancy outcomes in pre-eclamptic women. Methods Pre-eclamptic women were identified by interrogation of the Medical Registry Department in six French maternities between April 2013 and June 2018. Histological parameters in placentas (weight, macroscopic and microscopic lesions), baseline maternal characteristics and pregnancy outcomes (course of pregnancy, newborns’ characteristics) were collected. Biological parameters were blood cell ratios (Platelet-to-Lymphocyte Ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR)) collected at delivery and Placental growth factor (PlGF) measured in women with an available first trimester serum sample. Correlations of blood cell ratios and PlGF levels with placental parameters and pregnancy outcomes were assessed by Pearson’s correlation test for quantitative parameters and by logistic regression analysis for qualitative parameters. Results 202 pregnancies were included, among which 68 had a first trimester PlGF quantification. No correlation was found between biological parameters and placental lesions. Low PLR was correlated with low placental weight (r = 0.156, p = 0.036) and with low birth weight (r = 0.179, p = 0.015). Low PlGF was correlated with long time from pre-eclampsia diagnosis to delivery (r = −0.250, p = 0.048). Conclusions There is no correlation between biological parameters and placental lesions in pre-eclamptic women. Yet, low PLR at delivery is correlated with low placental and birth weights. Moreover, low first trimester PlGF is correlated with long time from pre-eclampsia diagnosis to delivery.
- Subjects :
- Placental growth factor
Adult
medicine.medical_specialty
Adolescent
Birth weight
[SDV]Life Sciences [q-bio]
Placenta
030204 cardiovascular system & hematology
Logistic regression
Correlation
03 medical and health sciences
Young Adult
0302 clinical medicine
Pre-Eclampsia
Pregnancy
Internal Medicine
medicine
Humans
Lymphocyte Count
Registries
Neutrophil to lymphocyte ratio
Placenta Growth Factor
030219 obstetrics & reproductive medicine
Obstetrics
business.industry
Platelet Count
Infant, Newborn
Obstetrics and Gynecology
Organ Size
Infant, Low Birth Weight
Middle Aged
medicine.disease
3. Good health
Low birth weight
Pregnancy Trimester, First
medicine.anatomical_structure
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 22107797 and 22107789
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Pregnancy hypertension
- Accession number :
- edsair.doi.dedup.....38a32c44464920af4edb9d966663deb0