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The prognostic role of the pre-treatment neutrophil to lymphocyte ratio (NLR) and tumor depth of invasion (DOI) in early-stage squamous cell carcinomas of the oral tongue
- Publication Year :
- 2022
-
Abstract
- The appropriate surgical management of early-stage oral tongue squamous cell carcinoma (OTSCC) remains a debated topic. The aim of this study is to investigate the role of the pre-treatment neutrophil to lymphocyte ratio (NLR) and tumor depth of invasion (DOI) in predicting the presence of occult neck metastases in early-stage OTSCC. A retrospective analysis of patients affected by early-stage (cT1-T2 cN0) OTSCC who were submitted to elective neck dissection (END) was performed. Tumors were classified retrospectively according to the 8th TNM classification, the DOI was assessed on the pre-operative magnetic resonance imaging, and the pre-treatment NLR was calculated for each patient. A logistic regression model to estimate the probability π (x) of cervical metastases by studying the NLR and DOI was carried out. Next, the correlation between the two variables, the NLR and DOI, was preliminarily studied. A cohort of 110 patients was analyzed (mean age, 62 years old; male to female ratio 1.2:1). The patients were staged as cT1 in 53 cases and cT2 in 57 cases. A DOI greater than 5.4 mm and a NLR greater than 2.93 are associated with an increased risk of presenting occult cervical metastases. Furthermore, the variables NLR and DOI are linearly associated with a positive correlation, proved by Spearman's rank correlation coefficient rho of 0.64, with a unitary increase in the DOI of 1 mm directly associated with an increase of 0.47 in the NLR. The DOI and NLR can be effectively used to predict the occurrence of occult neck metastasis and therefore to plan an END in early-stage OTSCC.
- Subjects :
- Male
Oncology
medicine.medical_specialty
Depth of invasion (DOI)
Neutrophils
medicine.medical_treatment
Metastasis
03 medical and health sciences
0302 clinical medicine
Tongue
Internal medicine
Neutrophil to lymphocyte ratio (NLR)
Occult neck metastasis
Oral tongue squamous cell carcinoma
Female
Humans
Lymphocytes
Middle Aged
Neoplasm Staging
Prognosis
Retrospective Studies
Carcinoma, Squamous Cell
Head and Neck Neoplasms
Tongue Neoplasms
medicine
Stage (cooking)
Neutrophil to lymphocyte ratio
Occult neck metastasi
030223 otorhinolaryngology
business.industry
Carcinoma
fungi
Neck dissection
030206 dentistry
medicine.disease
Occult
humanities
medicine.anatomical_structure
Squamous Cell
Otorhinolaryngology
Cohort
Oral and maxillofacial surgery
Surgery
Oral Surgery
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....38984e6efb9c2fe022dfa9046356cbff