Integrative single-cell mapping of combinatorial target antigens for logical CAR switches

This is the collection of datasets described in the paper "Integrative single-cell mapping of combinatorial target antigens for logical CAR switches" This repository contains thescRNA-seq matrix in h5ad format The description for each item are as follows: tumor-normal_meta-atlas_car-switch_geosketch_bbknn.h5ad.xz: Subsampled and batch-corrected matrix normal_meta-atlas_raw.h5ad.xz: Raw normal meta-atlas scRNA-seq dataset of401,717 cells tumor_meta-atlas_raw.h5ad.xz: Raw tumor meta-atlas scRNA-seq dataset of1,007,414 cells Ovarian cancer single-cell transcriptome data generated in this work is available on the Gene Expression Omnibus (GEO) with the accession number GSE192898. Source codes for CAR antigen identification, named PCASA (Prioritization of combinatorial Cancer-Associated Surface Antigens), are available on GitHub at https://github.com/kaistomics/PCASA.