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Phase II trial of flutamide in advanced ovarian cancer: an EORTC Gynaecological Cancer Cooperative Group study
- Source :
- European journal of cancer (Oxford, England : 1990). (7)
- Publication Year :
- 1994
-
Abstract
- New active non-toxic therapeutic regimens are warranted in ovarian cancer relapsing after platinum-based chemotherapy. Some investigators have determined that androgen receptors predominated over oestrogen and progesterone receptors in untreated common epithelial ovarian cancer tissue cytosols. In an effort to test its antitumoural activity, 68 pretreated patients with epithelial ovarian cancer were given flutamide 750 mg/day orally for at least 2 months. Of 32 patients who received a minimum of 2 months of therapy, pretreated with at least one platinum-based chemotherapy, and a median of two chemotherapy regimens, two (6.3%) objective responses (one complete and one partial) and nine (28%) disease stabilisations were observed; these lasted 44 and 72 weeks, respectively (for the complete and partial response), and for a median of 24 weeks for stabilisations (range 12-48+). Nausea and vomiting were the most frequent side-effects. These occurred in 19/55 (34.5%) patients evaluable for toxicity. Flutamide has to be considered ineffective in patients extensively pretreated with chemotherapy, and it is not devoid of side-effects.
- Subjects :
- Adult
Cancer Research
medicine.medical_specialty
Nausea
medicine.medical_treatment
Ovary
Antineoplastic Agents
Gastroenterology
Metastasis
Flutamide
chemistry.chemical_compound
Internal medicine
Medicine
Humans
Aged
Gynecology
Aged, 80 and over
Ovarian Neoplasms
Chemotherapy
business.industry
Middle Aged
medicine.disease
Androgen receptor
medicine.anatomical_structure
Treatment Outcome
Oncology
chemistry
Vomiting
Female
medicine.symptom
business
Ovarian cancer
Subjects
Details
- ISSN :
- 09598049
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- European journal of cancer (Oxford, England : 1990)
- Accession number :
- edsair.doi.dedup.....388fd0b9ba5653ed7319593896c10929