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Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method
- Source :
- Journal of Biomedical Optics. 18:111417
- Publication Year :
- 2013
- Publisher :
- SPIE-Intl Soc Optical Eng, 2013.
-
Abstract
- Damage of collagen fibers in tendons is often directly related to changes in a tendon's mechanical properties. Direct quantitative elasticity measurement of tendons will provide important information in tendon dysfunction diagnosis and treatment assessment. A feasibility study of quantifying the mechanical properties of a degenerated tendon model by a nondestructive imaging modality, which combines optical coherence elastography and acoustic radiation force (ARF) method, is presented. The degenerated tendon model was produced by the partial degradation of chicken tendons through incubation with collagenase at different concentrations and incubation times. A 30-kHz longitudinal ultrasound transducer was used to provide an ARF signal, which was detected by an ultra-high sensitive phase sensitive optical coherence tomography (PhS-OCT) system. The experimental results demonstrate that the combination of ARF method and PhS-OCT can measure the elasticity of tendon quantitatively. The corresponding changes in tendon elasticity due to the application of collagenase have been revealed by this new imaging modality. This method can potentially be used in the assessment of tissue engineering products and in the diagnosis and treatment progression of tendon diseases.
- Subjects :
- musculoskeletal diseases
Materials science
Biomedical Engineering
Signal-To-Noise Ratio
Models, Biological
Tendons
Biomaterials
Optics
Tissue engineering
Optical coherence tomography
Elastic Modulus
medicine
Animals
Elasticity (economics)
Acoustic radiation force
medicine.diagnostic_test
Phantoms, Imaging
business.industry
musculoskeletal system
Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Tendon
Agar
medicine.anatomical_structure
Transducer
Elasticity Imaging Techniques
Ultrasonic sensor
sense organs
Elastography
business
Chickens
Tomography, Optical Coherence
Biomedical engineering
Subjects
Details
- ISSN :
- 10833668
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Optics
- Accession number :
- edsair.doi.dedup.....388d42ebf543ebe3b3e8c3a52231a1ac