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Altered cardiac repolarization during exercise in congenital aortic stenosis
- Source :
- Pediatric Cardiology. 14:23-27
- Publication Year :
- 1993
- Publisher :
- Springer Science and Business Media LLC, 1993.
-
Abstract
- The incidence of sudden death in children with congenital aortic stenosis (CAS) varies between 4 and 20%. In several syndromes sudden death is associated with a long QT interval in the electrocardiogram (ECG). The aim of the study was to evaluate the cardiac repolarization in CAS during stress. We included 40 children and young persons, 20 with CAS and 20 healthy controls. All underwent echocardiographic study and treadmill stress test. The QT and relative RR intervals were measured in leads II and V6 at rest and during exercise at preselected heart rates. Mean values of QT were compared by analysis of variance, Student's t-test, and linear regression method. No statistically significant differences in the resting ECG were found between the two groups, whereas during exercise the mean QT of the CAS group was significantly longer than in the controls (p0.05), except at a heart rate of 140 +/- 5. Our study demonstrates that patients with CAS have transiently altered cardiac repolarization when there are sudden variations in heart rate. Such a defect could predispose patients with CAS to fatal arrhythmias and sudden death.
- Subjects :
- medicine.medical_specialty
Benign early repolarization
Congenital aortic stenosis
Cardiac repolarization
QT interval
Sudden death
Electrocardiography
Heart Conduction System
Heart Rate
Internal medicine
medicine
Humans
cardiovascular diseases
Child
Exercise
business.industry
Incidence
Incidence (epidemiology)
Aortic Valve Stenosis
Vascular surgery
Myocardial Contraction
Cardiac surgery
Death, Sudden, Cardiac
Echocardiography
Pediatrics, Perinatology and Child Health
Exercise Test
cardiovascular system
Cardiology
Regression Analysis
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 14321971 and 01720643
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Pediatric Cardiology
- Accession number :
- edsair.doi.dedup.....3879483adb85d0440a37cab7773aea85