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Polyarteritis nodosa, presenting as life-threatening gastrointestinal hemorrhage in a liver transplant recipient
- Source :
- Liver Transplantation. 14:151-154
- Publication Year :
- 2008
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2008.
-
Abstract
- This unique case reports the first recorded episode in the medical literature of vasculitis post-liver transplantation, presenting as life-threatening gastrointestinal hemorrhage. A 52-year-old Caucasian woman underwent orthotopic liver transplantation (OLT) for autoimmune cirrhosis complicated by hepatoma and portal vein thrombosis. Late hepatic artery thrombosis led to a second liver graft. Following recovery from an episode of acute rejection, the patient presented with large volume hematemesis, melena, and hemochezia (passage of fresh blood from the rectum). Following upper and lower gastrointestinal endoscopy and surgery, angiography illustrated the presence of polyarteritis nodosa (PAN), which was successfully treated with high-dose steroid therapy. Gastrointestinal hemorrhage is an unusual presentation of vasculitis, especially PAN. The occurrence of this phenomenon post-OLT, in the presence of immunosuppression is previously unreported.
- Subjects :
- Liver Cirrhosis
Reoperation
medicine.medical_specialty
Carcinoma, Hepatocellular
Cirrhosis
medicine.medical_treatment
Liver transplantation
Gastroenterology
Endoscopy, Gastrointestinal
Autoimmune Diseases
Hepatic Artery
Melena
Internal medicine
medicine
Humans
Venous Thrombosis
Transplantation
Hepatology
Portal Vein
business.industry
Polyarteritis nodosa
Liver Neoplasms
Rectum
Hematemesis
Middle Aged
medicine.disease
Liver Transplantation
Polyarteritis Nodosa
Surgery
Portal vein thrombosis
Radiography
Venous thrombosis
Treatment Outcome
surgical procedures, operative
Female
Steroids
medicine.symptom
Gastrointestinal Hemorrhage
business
Vasculitis
Subjects
Details
- ISSN :
- 15276473 and 15276465
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Liver Transplantation
- Accession number :
- edsair.doi.dedup.....38766ecb8b1f82657372251410cecb39