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Long-term Follow-up and Pattern of Failure for T1-T2 Glottic Cancer After Definitive Radiation Therapy
- Source :
- American Journal of Clinical Oncology. 36:580-583
- Publication Year :
- 2013
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2013.
-
Abstract
- To evaluate the impact of radiation therapy (RT) on the long-term outcomes and pattern of failure for T1-2 glottic cancer.This is a single-institution, retrospective study. From January (1997 to 2010), 253 patients with early glottic cancer underwent RT by 2-dimensional or 3-dimensional RT with Co or linear accelerator. Appropriate daily bolus was applied with linear accelerator-based RT to avoid under dosage of the anterior commissure.A total of 253 patients with T1-T2 glottic cancer were treated with definitive RT. The median age was 65 and males made up 87% of the population. T1 was 77% of the population. The median dose and fraction size were 63 and 2.25 Gy, respectively. After a median follow-up of 83 months, the locoregional control (LRC) for the whole cohort was 98%. Specifically, LRCs for T1 (195 patients) and T2 (58 patients) were 99.5% and 91%, respectively. Kaplan-Meier curve shows the 5-year cause-specific survival to be 100%.Single-modality RT provides an excellent and effective treatment for T1-T2 glottic cancer with remarkable functional preservation and 5-year LRC of 98% with negligible long-term toxicity.
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Long term follow up
medicine.medical_treatment
Cohort Studies
Internal medicine
otorhinolaryngologic diseases
medicine
Humans
Cobalt Radioisotopes
Laryngeal Neoplasms
Aged
Retrospective Studies
Aged, 80 and over
Patterns of failure
business.industry
Retrospective cohort study
Middle Aged
respiratory system
Definitive Radiation Therapy
Radiation therapy
Treatment Outcome
Glottic cancer
Female
Dose Fractionation, Radiation
Radiology
Radiotherapy, Conformal
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 02773732
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- American Journal of Clinical Oncology
- Accession number :
- edsair.doi.dedup.....38723c77003b4ee19d3c0b782734c12b