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Thin-Shelled PEGylated Perfluorooctyl Bromide Nanocapsules for Tumor-Targeted Ultrasound Contrast Agent
- Source :
- Contrast Media & Molecular Imaging, Vol 2018 (2018), Contrast Media & Molecular Imaging
- Publication Year :
- 2018
-
Abstract
- Shell thickness determines the acoustic response of polymer-based perfluorooctyl bromide (PFOB) nanocapsule ultrasound contrast agents. PEGylation provides stealth property and arms for targeting moieties. We investigated a modulation in the polymer formulation of carboxy-terminated poly(D,L-lactide-co-glycolide) (PLGA) and poly(D,L-lactide-co-glycolide)-block-polyethylene glycol (PLGA-b-PEG) to produce thin-shelled PFOB nanocapsules while keeping its echogenicity, stealth property, and active targeting potential. Polymer formulation contains 40% PLGA-PEG that yields the PEGylated PFOB nanocapsules of approximately 150 nm size with average thickness-to-radius ratio down to 0.15, which adequately hindered phagocytosis. Functionalization with antibody enables in vitro tumor-specific targeting. Despite the acoustic response improvement, the in vivo tumor accumulation was inadequate to generate an observable acoustic response to the ultrasound power at the clinical level. The use of PLGA and PLGA-PEG polymer blend allows the production of thin-shelled PFOB nanocapsules with echogenicity improvement while maintaining its potential for specific targeting.
- Subjects :
- lcsh:Medical technology
Article Subject
Antibodies, Neoplasm
Contrast Media
02 engineering and technology
macromolecular substances
Antigen-Antibody Complex
010402 general chemistry
01 natural sciences
Nanocapsules
Polyethylene Glycols
chemistry.chemical_compound
Mice
Drug Delivery Systems
In vivo
Cell Line, Tumor
Animals
Humans
Radiology, Nuclear Medicine and imaging
Polyglactin 910
Ultrasonography
chemistry.chemical_classification
Fluorocarbons
technology, industry, and agriculture
Echogenicity
Polymer
021001 nanoscience & nanotechnology
0104 chemical sciences
Hydrocarbons, Brominated
PLGA
RAW 264.7 Cells
chemistry
lcsh:R855-855.5
PEGylation
Surface modification
Heterografts
Polymer blend
0210 nano-technology
Research Article
Biomedical engineering
Subjects
Details
- ISSN :
- 15554317
- Volume :
- 2018
- Database :
- OpenAIRE
- Journal :
- Contrast mediamolecular imaging
- Accession number :
- edsair.doi.dedup.....386fcf37268bf07f2408046b0bcfabc1