Back to Search
Start Over
Phototherapy using immunologically modified carbon nanotubes to potentiate checkpoint blockade for metastatic breast cancer
- Source :
- Nanomedicine
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Metastasis is the major cause of cancer-death. Checkpoint inhibition shows great promise as an immunotherapeutic treatment for cancer patients. However, most currently available checkpoint inhibitors have low response rates. To augment the antitumor efficacy of checkpoint inhibitors, such as CTLA-4 antibodies, a single-walled carbon nanotube (SWNT) modified by a novel immunoadjuvant, glycated chitosan (GC), was used for the treatment of metastatic mammary tumors in mice. We treated the primary tumors by intratumoral administration of SWNT-GC, followed with irradiation with a 1064-nm laser to achieve local ablation through photothermal therapy (PTT). The treatment induced a systemic antitumor immunity which inhibited lung metastasis and prolonged the animal survival time of treated. Combining SWNT-GC-laser treatment with anti-CTLA-4 produced synergistic immunomodulatory effects and further extended the survival time of the treated mice. The results showed that the special combination, PTT + SWNT-GC + anti-CTLA, could effectively suppress primary tumors and inhibit metastases, providing a new treatment strategy for metastatic cancers.
- Subjects :
- medicine.medical_treatment
Biomedical Engineering
Pharmaceutical Science
Medicine (miscellaneous)
Apoptosis
Breast Neoplasms
Bioengineering
02 engineering and technology
Immunoadjuvant
Article
Metastasis
03 medical and health sciences
Breast cancer
Cell Line, Tumor
medicine
Animals
Humans
General Materials Science
Neoplasm Metastasis
030304 developmental biology
Chitosan
Mice, Inbred BALB C
0303 health sciences
Nanotubes, Carbon
business.industry
Immunity
Cancer
Immunotherapy
Phototherapy
Photothermal therapy
021001 nanoscience & nanotechnology
medicine.disease
Metastatic breast cancer
Blockade
Cancer research
Molecular Medicine
Female
0210 nano-technology
business
Subjects
Details
- ISSN :
- 15499634
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Nanomedicine: Nanotechnology, Biology and Medicine
- Accession number :
- edsair.doi.dedup.....38599f2e64ff28bd4fb595c2c7c6963d