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Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast
- Source :
- Nature Cell Biology. 4:32-41
- Publication Year :
- 2001
- Publisher :
- Springer Science and Business Media LLC, 2001.
-
Abstract
- Formins have been implicated in the regulation of cytoskeletal structure in animals and fungi. Here we show that the formins Bni1 and Bnr1 of budding yeast stimulate the assembly of actin filaments that function as precursors to tropomyosin-stabilized cables that direct polarized cell growth. With loss of formin function, cables disassemble, whereas increased formin activity causes the hyperaccumulation of cable-like filaments. Unlike the assembly of cortical actin patches, cable assembly requires profilin but not the Arp2/3 complex. Thus formins control a distinct pathway for assembling actin filaments that organize the overall polarity of the cell.
- Subjects :
- Saccharomyces cerevisiae Proteins
Arp2/3 complex
Saccharomyces cerevisiae
Spindle Apparatus
Tropomyosin
macromolecular substances
Biology
Filamin
Models, Biological
Fungal Proteins
Profilins
Contractile Proteins
Acetyltransferases
Gene Expression Regulation, Fungal
Cytoskeleton
N-Terminal Acetyltransferase B
Polarisome
Microfilament Proteins
fungi
Cell Polarity
Actin remodeling
Cell Biology
Endocytosis
Actins
Cell biology
Cytoskeletal Proteins
Profilin
Actin-Related Protein 3
Formins
Actin-Related Protein 2
Mutation
biology.protein
MDia1
Carrier Proteins
Cell Division
Subjects
Details
- ISSN :
- 14764679 and 14657392
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Nature Cell Biology
- Accession number :
- edsair.doi.dedup.....3856acfab52a024dd9684d19dc8f55d2