Back to Search
Start Over
IL-18 expression in clinical human pituitary adenoma
- Source :
- Technology and Health Care. 30:11-16
- Publication Year :
- 2021
- Publisher :
- IOS Press, 2021.
-
Abstract
- BACKGROUND: IL-18 is known as an interferon-inducing factor that belongs to the IL-1 family, and is synthesized as an inactive precursor protein. OBJECTIVE: The present study aims to investigate the expression of IL-18, IL-18R, R and IL-18 binding protein (BP) mRNA in various types of human pituitary tumors, such as adrenocorticotropic hormone (ACTH), growth hormone (GH), prolactin (PRL), thyroid stimulating hormone (TSH)-producing adenomas and non-function adenomas. METHODS: Pituitary adenoma tissues were obtained during the surgery of 41 patients: nine patients had ACTH-producing pituitary adenomas, nine patients had GH-producing pituitary adenomas, five patients had TSH-producing pituitary adenomas, seven patients had PRL-producing pituitary adenomas, and 11 patients had non-functioning adenomas. The mRNA expression levels of IL-18, IL-18BP, IL-18R and IL-18R were quantified using real-time quantitative PCR. RESULTS: The mRNA expression of IL-18 was significantly higher in ACTH-, GH- and PRL-producing adenomas, when compared to non-function tumors. Similarly, a significantly higher mRNA expression of IL-18BP and IL-18R was observed in ACTH-, GH- and PRL-producing adenomas, when compared with non-functional adenomas. In contrast, no upregulation of IL-18R mRNA was observed in any of the pituitary adenomas. CONCLUSIONS: The mRNA levels of IL-18, IL-18BP and IL-18R are significantly elevated in clinical pituitary tumors, such as ACTH-, GH- and PRL-producing adenomas, when compared to non-functional adenomas. These present results suggest the possibility that IL-18 may be involved in the pathogenesis of pituitary adenoma.
- Subjects :
- Adenoma
endocrine system
medicine.medical_specialty
endocrine system diseases
Biomedical Engineering
Biophysics
Health Informatics
Bioengineering
Adrenocorticotropic hormone
Biomaterials
03 medical and health sciences
0302 clinical medicine
Thyroid-stimulating hormone
Pituitary adenoma
Internal medicine
Gene expression
Humans
Medicine
Pituitary Neoplasms
Prolactinoma
030304 developmental biology
0303 health sciences
business.industry
Pituitary tumors
Interleukin-18
medicine.disease
digestive system diseases
Prolactin
stomatognathic diseases
Real-time polymerase chain reaction
Endocrinology
030220 oncology & carcinogenesis
business
hormones, hormone substitutes, and hormone antagonists
Information Systems
Hormone
Subjects
Details
- ISSN :
- 18787401 and 09287329
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Technology and Health Care
- Accession number :
- edsair.doi.dedup.....3853b443c5f785cd9cfff89f22f51846
- Full Text :
- https://doi.org/10.3233/thc-191967