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Shear stress-initiated signaling and its regulation of endothelial function
- Source :
- Zhou, J; Li, YS; & Chien, S. (2014). Shear stress-initiated signaling and its regulation of endothelial function. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(10), 2191-2198. doi: 10.1161/ATVBAHA.114.303422. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/3nq0q4p2, Arteriosclerosis, thrombosis, and vascular biology, vol 34, iss 10
- Publication Year :
- 2014
- Publisher :
- eScholarship, University of California, 2014.
-
Abstract
- © 2014 American Heart Association, Inc. Atherosclerosis develops preferentially at branches and curvatures of the arterial tree, where blood flow pattern is disturbed rather than being laminar, and wall shear stress has an irregular distribution without defined directions. The endothelium in the atherosusceptible regions, in comparison to that in atheroresistant regions, shows activation of proproliferative and proinflammatory gene expressions, reduced production of nitric oxide (NO), increased leukocyte adhesion, and permeability, as well as other atheroprone phenotypes. Differences in gene expressions and cell phenotypes have been detected in endothelia residing in native atherosusceptible and atheroresistant regions of the arteries, or in arteries from animal models with artificial creation of disturbed flow. Similar results have also been shown in in vitro systems that apply controlled shear stresses with or without clear directions to cultured endothelial cells in fluid-dynamically designed flow-loading devices. The available evidence indicates that the coordination of multiple signaling networks, rather than individual separate pathways, links the mechanical signals to specific genetic circuitries in orchestrating the mechanoresponsive networks to evoke comprehensive genetic and functional responses.
- Subjects :
- Endothelium
Mechanotransduction
Cell
Clinical Sciences
Bioengineering
Biology
Cardiorespiratory Medicine and Haematology
Stress
hemodynamics
Cardiovascular
Mechanotransduction, Cellular
cellular mechanotransduction
Article
Nitric oxide
Proinflammatory cytokine
chemistry.chemical_compound
Vascular
medicine
Shear stress
Genetics
Animals
Humans
2.1 Biological and endogenous factors
Aetiology
Regulation of gene expression
Hemodynamics
Endothelial Cells
Mechanical
Atherosclerosis
Phenotype
Arterial tree
Cell biology
medicine.anatomical_structure
chemistry
Gene Expression Regulation
Cardiovascular System & Hematology
Regional Blood Flow
Immunology
Endothelium, Vascular
Stress, Mechanical
Cellular
Cardiology and Cardiovascular Medicine
Biotechnology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Zhou, J; Li, YS; & Chien, S. (2014). Shear stress-initiated signaling and its regulation of endothelial function. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(10), 2191-2198. doi: 10.1161/ATVBAHA.114.303422. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/3nq0q4p2, Arteriosclerosis, thrombosis, and vascular biology, vol 34, iss 10
- Accession number :
- edsair.doi.dedup.....38510748caea7315a3e998be75415639