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The development and validation of the Leiden Bother and Needs Questionnaire for patients with pituitary disease: the LBNQ-Pituitary
- Source :
- Pituitary, Pituitary, 19, 293-302, Pituitary, 19, 3, pp. 293-302, Pituitary, 19(3), 293-302. SPRINGER
- Publication Year :
- 2016
-
Abstract
- Background Patients report persisting impairment in quality of life (QoL) after treatment for pituitary disease. At present, there is no questionnaire to assess (a) whether patients with pituitary disease are bothered by these consequences, and (b) their needs for support. Objective To develop and validate a disease-specific questionnaire for patients with pituitary disease which incorporates patient perceived bother related to the consequences of the disease, and their needs for support. Methods Items for the Leiden Bother and Needs Questionnaire for patients with pituitary disease (LBNQ-Pituitary) were formulated based on results of a recent focus group study (n = 49 items). 337 patients completed the LBNQ-Pituitary and six validated QoL questionnaires (EuroQoL-5D, SF-36, MFI-20, HADS, AcroQol, CushingQoL). Construct validity was examined by exploratory factor analysis. Reliabilities of the subscales were calculated with Cronbach’s alphas, and concurrent validity was assessed by calculating Spearman’s correlations between the LBNQ-Pituitary and the other measures. Results Factor analyses produced five subscales (i.e., mood problems, negative illness perceptions, issues in sexual functioning, physical and cognitive complaints, issues in social functioning) containing a total of 26 items. All factors were found to be reliable (Cronbach’s alphas all ≥.765), and the correlations between the dimensions of the LBNQ-Pituitary and other questionnaires (all P ≤ .0001) demonstrated convergent validity. Conclusions The LBNQ-Pituitary can be used to assess the degree to which patients are bothered by the consequences of the pituitary disease, as well as their needs for support. It could also facilitate an efficient assessment of patients’ needs for support in clinical practice. We postulate that paying attention to needs for support will lead to optimal patient care (e.g., improvement in psychosocial care), and positively affect QoL. Electronic supplementary material The online version of this article (doi:10.1007/s11102-016-0707-4) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
Pituitary disease
Endocrinology, Diabetes and Metabolism
Pituitary Diseases
Cushing's syndrome
Pituitary neoplasm
0302 clinical medicine
Endocrinology
Cognition
Quality of life
Surveys and Questionnaires
Patient-reported outcome
Patient-reported-outcome
Pituitary adenomas
Middle Aged
Cushing’s disease
humanities
Reproductive Health
Convergent validity
030220 oncology & carcinogenesis
Cushing's disease
Female
Needs Assessment
Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Clinical psychology
Adenoma
Adult
medicine.medical_specialty
Antineoplastic Agents, Hormonal
Hormone Replacement Therapy
Non-functioning pituitary macroadenoma
Concurrent validity
030209 endocrinology & metabolism
RT
Hypopituitarism
Article
03 medical and health sciences
Cronbach's alpha
Internal medicine
medicine
Humans
Pituitary Neoplasms
Prolactinoma
Patient Reported Outcome Measures
Pituitary ACTH Hypersecretion
Social Behavior
Aged
Hypophysectomy
Radiotherapy
business.industry
Construct validity
Reproducibility of Results
medicine.disease
Affect
Cushing’s syndrome
Acromegaly
Cranial Irradiation
Growth Hormone-Secreting Pituitary Adenoma
business
Factor Analysis, Statistical
Needs
Illness perceptions
RC
Subjects
Details
- ISSN :
- 15737403 and 1386341X
- Volume :
- 19
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Pituitary
- Accession number :
- edsair.doi.dedup.....384ed0f15bd29a33fe19bba5502cad86