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Dependence on morphine impairs the induction of long-term potentiation in the CA1 region of rat hippocampal slices
- Source :
- Brain Research. 965:108-113
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- The effect of chronic morphine treatment on hippocampal CA1-long-term potentiation (LTP) was examined in vitro. The field excitatory postsynaptic potential (fEPSP) was recorded from stratum radiatum of area CA1 following stimulation of Schaffer collaterals in slices taken from control and morphine-dependent rats. To induce LTP, a 100-Hz primed burst stimulation (PBs) was used. Slices from rats exposed to chronic morphine showed no effect on baseline synaptic responses. Slices from control rats or rats exposed to chronic morphine maintained in ACSF with either morphine or naloxone also had no effect on baseline synaptic responses. Control slices perfused with medium containing either morphine or naloxone as well as both drugs exhibited hippocampal CA1 LTP. Similarly, slices from morphine-dependent rats maintained in ACSF with either naloxone or just morphine free ACSF also exhibited hippocampal CA1 LTP. However, slices from morphine-dependent rats maintained in ACSF with morphine significantly attenuated hippocampal CA1 LTP. These findings suggest that hippocampal CA1-LTP can still be achieved in slices from morphine-dependent rats exhibiting morphine withdrawal through mechanisms that may be inhibited by opiate exposure. Such studies can be helpful in understanding the neurophysiological substrate of memory deficits seen in opiate addicts.
- Subjects :
- Male
Long-Term Potentiation
Stimulation
(+)-Naloxone
In Vitro Techniques
Pharmacology
Hippocampal formation
Hippocampus
medicine
Animals
Molecular Biology
Morphine
Chemistry
musculoskeletal, neural, and ocular physiology
General Neuroscience
Excitatory Postsynaptic Potentials
Long-term potentiation
Rats
nervous system
Synaptic plasticity
Excitatory postsynaptic potential
Neurology (clinical)
Opiate
Morphine Dependence
Developmental Biology
medicine.drug
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 965
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi.dedup.....384d2ed2072bb4a80a3533e962636fd0