Colloidal gold immunochromatographic assay (GICA) is an effective screening method for identifying detectable anti-SARS-CoV-2 neutralizing antibodies

Authors :: Shuyun Xu
Fengmin Lu
Tao Shen
Xinjie Li
Dong Xu
Ling Pang
Yue Yin
Source :: International Journal of Infectious Diseases, International Journal of Infectious Diseases, Vol 108, Iss, Pp 483-486 (2021)
Publication Year :: 2021
Publisher :: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases., 2021.
Abstract: Introduction A large number of COVID-19 patients are in recovery and millions of people are vaccinated COVID-19 vaccines globally daily. This calls for a rapid screening strategy of SARS-CoV-2 protective antibodies generated in rehabilitators and vaccinated populations. Methods Serum samples collected over a follow-up period of 6 months from 306 COVID-19 cases discharged from Wuhan Tongji Hospital were analyzed. Anti-S Abs were detected by colloidal gold immunochromatographic assay (GICA) and neutralizing antibodies (nAbs) were detected by chemiluminescent microparticle immunoassay (CMIA). Results Most COVID-19 survivors tested positive for anti-S Abs (83.7%) and nAbs (98.0%) 6 months after being discharged from the hospital, and the levels of anti-S Abs in the blood were highly positively correlated with nAbs (r = 0.652, P

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