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Reactions of 3,4-Estrone Quinone with Mimics of Amino Acid Side Chains
- Source :
- Chemical Research in Toxicology. 9:434-438
- Publication Year :
- 1996
- Publisher :
- American Chemical Society (ACS), 1996.
-
Abstract
- Reaction of 3,4-estrone o-quinone (3,4-EQ) with several amino acid side chain mimics, including 4-ethylphenol, 4-methylimidazole, acetic acid, and propanethiol, gave a mixture of several products including the catechol, Michael addition products, and dimeric products of the catechol. On the other hand, several other amino acid side chain mimics, including ethanol, acetamide, 1-ethylguanidine, and 3-methylindole, did not result in any addition products or catechol formation. Michael addition to 3,4-EQ with 4-methylimidazole, acetate, and 4-ethyl phenoxide resulted in 1,4-addition, leading to C-1 adducts while reaction with propanethiol gave the C-2 addition product.
- Subjects :
- chemistry.chemical_classification
Chemistry
Stereochemistry
musculoskeletal, neural, and ocular physiology
Propanethiol
Estrone
macromolecular substances
General Medicine
Toxicology
Photo-reactive amino acid analog
Quinone
Amino acid
chemistry.chemical_compound
Acetic acid
Models, Chemical
nervous system
Biochemistry
Amino acid side chain
Side chain
Amino Acids
Estrenes
Subjects
Details
- ISSN :
- 15205010 and 0893228X
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Chemical Research in Toxicology
- Accession number :
- edsair.doi.dedup.....38458493f20bbc6c970404cacffb8f15