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Contribution of HLA class II genes to susceptibility in achalasia
- Source :
- Tissue Antigens. 52:381-384
- Publication Year :
- 1998
- Publisher :
- Wiley, 1998.
-
Abstract
- Achalasia is a motor disorder of the esophagus resulting in functional obstruction. The cause of the lesion is unknown although genetic and immunologic factors have been suggested. An association with serological HLA epitopes has been previously reported. In this study, we have further examined this HLA class II association with susceptibility to achalasia by DNA based methods. Achalasia patients (n=40) and healthy controls (n=275), all Caucasians and unrelated, were included in the analysis. The strongest associations were with HLA-DQA1*0101 and two HLA-DQ alphabeta heterodimers having their alpha chain encoded by this allele. Moreover, relative risk was significantly higher in DQA1*0101 homozygotes as compared to heterozygotes and results suggested that DQB1*02 may have a protective role.
- Subjects :
- Heterozygote
Pathology
medicine.medical_specialty
Genes, MHC Class II
Immunology
Achalasia
Human leukocyte antigen
Biochemistry
HLA-DQ alpha-Chains
Epitope
Lesion
Gene Frequency
HLA-DQ Antigens
otorhinolaryngologic diseases
Genetics
medicine
HLA-DQ beta-Chains
Humans
Immunology and Allergy
Genetic Predisposition to Disease
Esophagus
Allele
Alleles
business.industry
Homozygote
Heterozygote advantage
HLA-DR Antigens
General Medicine
medicine.disease
Esophageal Achalasia
medicine.anatomical_structure
Haplotypes
Spain
medicine.symptom
business
Dimerization
Alpha chain
Subjects
Details
- ISSN :
- 13990039 and 00012815
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Tissue Antigens
- Accession number :
- edsair.doi.dedup.....3843696d4ba4b8658bec1c7013fdf8fb