A pharmacological strategy to recapitulate exercise-induced antitumoral immunity

Authors :: Amélie Rébillard
Jacques A. Nunès
Alice Carrier
Pôle de Formation des Professionnels de Santé du Centre hospitalier de Rennes (PFPS)
Laboratoire Mouvement Sport Santé (M2S)
Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Réseau National Alimentation Cancer Recherche (réseau NACRe)
Institut Paoli-Calmettes
Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)
Source :: Trends in Pharmacological Sciences, Trends in Pharmacological Sciences, 2022, ⟨10.1016/j.tips.2022.08.004⟩
Publication Year :: 2022
Abstract: International audience; The antitumor activity of exercise by means of enhanced immune activation is documented, but better identification of the underlying mechanisms is required to develop new therapeutic strategies. Recent work from the Dr Bar-Sagi group reveals that exercise engages IL-15 signaling and pharmacological activation of the IL-15/IL-15R axis mimics the exercise-driven immune cell-mediated cytotoxicity in pancreatic cancer.

Subjects :: Pharmacology
immunology
Interleukin-15
[SDV]Life Sciences [q-bio]
pancreatic cancer
physical activity
Humans
Toxicology
IL-15 superagonist
Signal Transduction

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