Back to Search
Start Over
Development of Human Fetal Skin Transplanted to the Nude Mouse
- Source :
- Journal of Investigative Dermatology. 93(6):787-791
- Publication Year :
- 1989
- Publisher :
- Elsevier BV, 1989.
-
Abstract
- Thirty-five human fetal skin (HFS) grafts were transplanted to nude mice for 7 to 70 d and evaluated histologically with 64 biopsies. The estimated gestational ages (EGS) of the grafts at the time of the transplantation ranged from 8 to 19 weeks. The maturation of the engrafted fetal skin was evaluated by assessing epidermal, dermal, and appendage development. Within the nude mouse, the HFS demonstrated progression in stratification and maturation of the epidermis. The dermis increased in depth, adding fibrovascular stroma and adipose tissue. The appendages demonstrated invagination, differentiation, and progression of organogenesis. Subcutaneously placed grafts showed the same rate of HFS development as HFS in utero. The grafts transplanted to the surface of the nude mice and exposed to air demonstrated an acceleration of development. We conclude that HFS transplanted to the nude mouse is an effective in vivo model for maintaining and altering HFS maturation.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Biopsy
Transplantation, Heterologous
Adipose tissue
Mice, Nude
Dermatology
Biochemistry
030207 dermatology & venereal diseases
03 medical and health sciences
Mice
0302 clinical medicine
Nude mouse
Fetus
Dermis
Stroma
medicine
Animals
Humans
Molecular Biology
030304 developmental biology
0303 health sciences
biology
Epidermis (botany)
integumentary system
business.industry
Skin Transplantation
Cell Biology
biology.organism_classification
3. Good health
Transplantation
medicine.anatomical_structure
surgical procedures, operative
In utero
Regression Analysis
business
Subjects
Details
- ISSN :
- 0022202X
- Volume :
- 93
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of Investigative Dermatology
- Accession number :
- edsair.doi.dedup.....3830f5dcda6877e480c884c1a33bf46c
- Full Text :
- https://doi.org/10.1111/1523-1747.ep12284423