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Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection
- Source :
- Biomaterials. 29:2548-2555
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe 2 O 4 magnetic nanocrystals encapsulated in pyrene-labeled PCL- b -PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.
- Subjects :
- Materials science
Biocompatibility
Polyesters
Biophysics
Cetuximab
Bioengineering
Nanotechnology
Epithelial cancer
Conjugated system
Antibodies, Monoclonal, Humanized
Biomaterials
Optical imaging
Polymethacrylic Acids
Cell Line, Tumor
medicine
Humans
Fluorescent Dyes
Multimodal imaging
Pyrenes
medicine.diagnostic_test
Antibodies, Monoclonal
Epithelial Cells
Magnetic resonance imaging
Flow Cytometry
equipment and supplies
Magnetic Resonance Imaging
Fluorescence
ErbB Receptors
Microscopy, Fluorescence
Mechanics of Materials
Ceramics and Composites
Nanoparticles
Cancer cell lines
human activities
Subjects
Details
- ISSN :
- 01429612
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Biomaterials
- Accession number :
- edsair.doi.dedup.....3827adef88dc88224b30aa70cdec5043