Anti-human CD117 antibody-mediated bone marrow niche clearance in nonhuman primates and humanized NSG mice

Authors :: Benjamin V. Kelly
Judith A. Shizuru
Roger P. Hollis
Alan Le
Wendy W. Pang
Irving L. Weissman
Susan S. Prohaska
Jessica Poyser
Akanksha Chhabra
Donald B. Kohn
Agnieszka Czechowicz
Hye-Sook Kwon
Keri Tate
Aaron C Logan
Source :: Blood
Publication Year :: 2019
Publisher :: American Society of Hematology, 2019.
Abstract: TO THE EDITOR: Successful engraftment of hematopoietic stem cells (HSCs) involves overcoming nonimmunologic barriers that hinder access to the HSC niches in the bone marrow (BM).[1][1],[2][2] Cytotoxic chemotherapy and/or radiation are currently used to reduce these barriers in clinical

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