Back to Search
Start Over
A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score
- Source :
- Cancers, Vol 12, Iss 4, p 783 (2020), Cancers, Cancers, 2020, 12 (4), pp.783. ⟨10.3390/cancers12040783⟩, Cancers, MDPI, 2020, 12 (4), pp.783. ⟨10.3390/cancers12040783⟩, Volume 12, Issue 4
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Surgery remains the only curative treatment for pancreatic ductal adenocarcinoma (PDAC). Therefore, a predictive score for resectability on diagnosis is needed. A total of 814 patients were included between 2014 and 2017 from 15 centers included in the BACAP (the national Anatomo-Clinical Database on Pancreatic Adenocarcinoma) prospective cohort. Three groups were defined: resectable (Res), locally advanced (LA), and metastatic (Met). Variables were analyzed and a predictive score was devised. Of the 814 patients included, 703 could be evaluated: 164 Res, 266 LA, and 273 Met. The median ages of the patients were 69, 71, and 69, respectively. The median survival times were 21, 15, and nine months, respectively. Six criteria were significantly associated with a lower probability of resectability in multivariate analysis: venous/arterial thrombosis (p = 0.017), performance status 1 (p = 0.032) or ≥ 2 (p = 0.010), pain (p = 0.003), weight loss ≥ 8% (p = 0.019), topography of the tumor (body/tail) (p = 0.005), and maximal tumor size 20–33 mm (p &lt<br />0.013) or &gt<br />33 mm (p &lt<br />0.001). The BACAP score was devised using these criteria (http://jdlp.fr/resectability/) with an accuracy of 81.17% and an area under the receive operating characteristic (ROC) curve of 0.82 (95% confidence interval (CI): 0.78<br />0.86). The presence of pejorative criteria or a BACAP score &lt<br />50% indicates that further investigations and even neoadjuvant treatment might be warranted. Trial registration: NCT02818829.
- Subjects :
- Cancer Research
medicine.medical_specialty
predictive factors
Multivariate analysis
[SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery
pancreatic cancer
pancreatic ductal adenocarcinoma
[SDV.CAN]Life Sciences [q-bio]/Cancer
[SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery
lcsh:RC254-282
Gastroenterology
Article
03 medical and health sciences
0302 clinical medicine
[SDV.CAN] Life Sciences [q-bio]/Cancer
bacap cohort
Weight loss
locally advanced
Internal medicine
Pancreatic cancer
medicine
metastasis
score
Prospective cohort study
resectability
Performance status
business.industry
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Thrombosis
[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Confidence interval
3. Good health
Oncology
030220 oncology & carcinogenesis
Adenocarcinoma
030211 gastroenterology & hepatology
medicine.symptom
business
Subjects
Details
- ISSN :
- 20726694
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....3819ed184b378fca57b1dadb6fa2a98f