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Antibody-mediated vascular rejection of kidney allografts: a population-based study
- Source :
- Lancet (London, England). 381(9863)
- Publication Year :
- 2012
-
Abstract
- Rejection of allografts has always been the major obstacle to transplantation success. We aimed to improve characterisation of different kidney-allograft rejection phenotypes, identify how each one is associated with anti-HLA antibodies, and investigate their distinct prognoses.Patients who underwent ABO-compatible kidney transplantations in Necker Hospital and Saint-Louis Hospital (Paris, France) between Jan 1, 1998, and Dec 31, 2008, were included in our population-based study. We assessed patients who provided biopsy samples for acute allograft rejection, which was defined as the association of deterioration in function and histopathological lesions. The main outcome was kidney allograft loss-ie, return to dialysis. To investigate distinct rejection patterns, we retrospectively assessed rejection episodes with review of graft histology, C4d in allograft biopsies, and donor-specific anti-HLA antibodies.2079 patients were included in the main analyses, of whom 302 (15%) had acute biopsy-proven rejection. We identified four distinct patterns of kidney allograft rejection: T cell-mediated vascular rejection (26 patients [9%]), antibody-mediated vascular rejection (64 [21%]), T cell-mediated rejection without vasculitis (139 [46%]), and antibody-mediated rejection without vasculitis (73 [24%]). Risk of graft loss was 9·07 times (95 CI 3·62-19·7) higher in antibody-mediated vascular rejection than in T cell-mediated rejection without vasculitis (p0·0001), compared with an increase of 2·93 times (1·1-7·9; P=0·0237) in antibody-mediated rejection without vasculitis and no significant rise in T cell-mediated vascular rejection (hazard ratio [HR] 1·5, 95% CI 0·33-7·6; p=0·60).We have identified a type of kidney rejection not presently included in classifications: antibody-mediated vascular rejection. Recognition of this distinct phenotype could lead to the development of new treatment strategies that could salvage many kidney allografts.None.
- Subjects :
- Graft Rejection
Male
medicine.medical_specialty
medicine.medical_treatment
Population
Gastroenterology
Endarteritis
HLA Antigens
Isoantibodies
Internal medicine
Biopsy
medicine
Humans
education
Dialysis
education.field_of_study
Kidney
biology
medicine.diagnostic_test
business.industry
Histology
General Medicine
Middle Aged
medicine.disease
Kidney Transplantation
Surgery
Transplantation
medicine.anatomical_structure
CD4 Antigens
biology.protein
Female
Antibody
business
Vasculitis
Subjects
Details
- ISSN :
- 1474547X
- Volume :
- 381
- Issue :
- 9863
- Database :
- OpenAIRE
- Journal :
- Lancet (London, England)
- Accession number :
- edsair.doi.dedup.....38072c0909d5ca3e92c2a7a7d9f3b86f