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Bioactive Glasses: From Parent 45S5 Composition to Scaffold-Assisted Tissue-Healing Therapies
- Source :
- Journal of Functional Biomaterials, Vol 9, Iss 1, p 24 (2018), Journal of Functional Biomaterials
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- Nowadays, bioactive glasses (BGs) are mainly used to improve and support the healing process of osseous defects deriving from traumatic events, tumor removal, congenital pathologies, implant revisions, or infections. In the past, several approaches have been proposed in the replacement of extensive bone defects, each one with its own advantages and drawbacks. As a result, the need for synthetic bone grafts is still a remarkable clinical challenge since more than 1 million bone-graft surgical operations are annually performed worldwide. Moreover, recent studies show the effectiveness of BGs in the regeneration of soft tissues, too. Often, surgical criteria do not match the engineering ones and, thus, a compromise is required for getting closer to an ideal outcome in terms of good regeneration, mechanical support, and biocompatibility in contact with living tissues. The aim of the present review is providing a general overview of BGs, with particular reference to their use in clinics over the last decades and the latest synthesis/processing methods. Recent advances in the use of BGs in tissue engineering are outlined, where the use of porous scaffolds is gaining growing importance thanks to the new possibilities given by technological progress extended to both manufacturing processes and functionalization techniques.
- Subjects :
- Scaffold
Materials science
lcsh:Biotechnology
Biomedical Engineering
02 engineering and technology
Review
scaffold
010402 general chemistry
01 natural sciences
Biomaterials
Tissue engineering
lcsh:TP248.13-248.65
silicate glass
drug release
lcsh:R5-920
borate glass
Regeneration (biology)
mesoporous bioactive glass
Synthetic bone
Bioglass
glass-ceramic
021001 nanoscience & nanotechnology
Porous scaffold
0104 chemical sciences
Processing methods
sol–gel
Risk analysis (engineering)
tissue engineering
Tissue healing
Tumor removal
0210 nano-technology
lcsh:Medicine (General)
phosphate glass
Subjects
Details
- Language :
- English
- ISSN :
- 20794983
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Functional Biomaterials
- Accession number :
- edsair.doi.dedup.....3803218b536ebf79b9557a2f967b56ce